Evidence map›Paper›PMID 27232077›Full record

ReviewEar and hearing

The Physiological Basis and Clinical Use of the Binaural Interaction Component of the Auditory Brainstem Response.

Geneviève Laumen, Alexander T Ferber, Georg M Klump, Daniel J Tollin

Abstract readReview
In one paragraph

Review in Ear and hearing. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 82 citations in OpenAlex.

  1. The effects of interaural time and level differences on the binaural interaction component of the auditory brainstem response in Cope's gray treefrogs.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026
    Article
  2. Article
  3. Presynaptic CabioRxiv : the preprint server for biology · 2026
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  12. Age-Related Deficits in Binaural Hearing: Contribution of Peripheral and Central Effects.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  13. Article
  14. Hearing ability of prairie voles (Microtus ochrogaster).The Journal of the Acoustical Society of America · 2024
    Article
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  18. Mitigation of Hearing Damage After Repeated Blast Exposures in Animal Model of Chinchilla.Journal of the Association for Research in Otolaryngology : JARO · 2022
    Article
  19. Auditory brainstem development of naked mole-rats (Proceedings. Biological sciences · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Geneviève Laumen *Cluster of Excellence Hearing4all, Animal Physiology and Behavior Group, Department for Neuroscience, School of Medicine and Health Sciences, Oldenburg University, 26111 Oldenburg, Germany.
Alexander T Ferber *Department of Physiology and Biophysics, School of Medicine, University of Colorado, Aurora, Colorado 80045, USA.
Georg M KlumpCluster of Excellence Hearing4all, Animal Physiology and Behavior Group, Department for Neuroscience, School of Medicine and Health Sciences, Oldenburg University, 26111 Oldenburg, Germany.
Daniel J TollinDepartment of Physiology and Biophysics, School of Medicine, University of Colorado, Aurora, Colorado 80045, USA.
Hearing4all · DEUniversity of Colorado Anschutz Medical Campus · US

Funding

Medical Scientist Training ProgramT32GM008497 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI WILSON, CARA C. · 1993 to 2022
$15.2M
Developmental effects of early hearing loss on auditory information processingR01DC011555 · NIDCD · UNIVERSITY OF COLORADO DENVER · PI KLUG, ACHIM, TOLLIN, DANIEL J · 2012 to 2021
$4.4M
NEUROSCIENCE TRAINING GRANTT32HD041697 · NICHD · UNIVERSITY OF COLORADO DENVER · PI RESTREPO, DIEGO · 2001 to 2015
$2.4M
Electrophysiological biomarkers for spatial hearing impairments resulting from eaF30DC013932 · NIDCD · UNIVERSITY OF COLORADO DENVER · PI FERBER, ALEXANDER T · 2014 to 2016
$94k
NICHD NIH HHS T32 HD041697NIDCD NIH HHS F30 DC013932NIDCD NIH HHS R01 DC011555NIGMS NIH HHS T32 GM008497
6 · The paper itself

Abstract

The auditory brainstem response (ABR) is a sound-evoked noninvasively measured electrical potential representing the sum of neuronal activity in the auditory brainstem and midbrain. ABR peak amplitudes and latencies are widely used in human and animal auditory research and for clinical screening. The binaural interaction component (BIC) of the ABR stands for the difference between the sum of the monaural ABRs and the ABR obtained with binaural stimulation. The BIC comprises a series of distinct waves, the largest of which (DN1) has been used for evaluating binaural hearing in both normal hearing and hearing-impaired listeners. Based on data from animal and human studies, the authors discuss the possible anatomical and physiological bases of the BIC (DN1 in particular). The effects of electrode placement and stimulus characteristics on the binaurally evoked ABR are evaluated. The authors review how interaural time and intensity differences affect the BIC and, analyzing these dependencies, draw conclusion about the mechanism underlying the generation of the BIC. Finally, the utility of the BIC for clinical diagnoses are summarized.

Indexed as

Acoustic StimulationAuditory PerceptionElectrodesEvoked Potentials, Auditory, Brain StemHearingHearing LossHumans

Identifiers

PMID27232077
PMCPMC4996694
OpenAlexW2401635211

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.