Evidence map›Paper›PMID 27231946›Full record

ArticleBiosensors2016

Broadband 120 MHz Impedance Quartz Crystal Microbalance (QCM) with Calibrated Resistance and Quantitative Dissipation for Biosensing Measurements at Higher Harmonic Frequencies.

Manuel Kasper, Lukas Traxler, Jasmina Salopek, Herwig Grabmayr, Andreas Ebner, Ferry Kienberger

Open access · goldAbstract read
In one paragraph

Article in Biosensors, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Manuel KasperKeysight Technologies Austria GmbH, Keysight Labs Linz, Gruberstrasse 40, 4020 Linz, Austria. manuel.kasper@keysight.com.
Lukas TraxlerJohannes Kepler University Linz, Biophysics Institute, Gruberstrasse 40, 4020 Linz, Austria. Lukas.Traxler@jku.at.
Jasmina SalopekFaculty of Science, Department of Chemistry, Division of Physical Chemistry University of Zagreb, Horvatovac 102a, 10000 Zagreb, Croatia. jsalopek@chem.pmf.hr.
Herwig GrabmayrJohannes Kepler University Linz, Biophysics Institute, Gruberstrasse 40, 4020 Linz, Austria. herwigreinhard.grabmayr@students.fh-wels.at.
Andreas EbnerJohannes Kepler University Linz, Biophysics Institute, Gruberstrasse 40, 4020 Linz, Austria. Andreas.Ebner@jku.at.
Ferry KienbergerKeysight Technologies Austria GmbH, Keysight Labs Linz, Gruberstrasse 40, 4020 Linz, Austria. ferry_kienberger@keysight.com.
Johannes Kepler University of Linz · ATKeysight Technologies (Austria) · ATUniversity of Applied Sciences Upper Austria · ATUniversity of Zagreb · HR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We developed an impedance quartz crystal microbalance (QCM) approach with the ability to simultaneously record mass changes and calibrated energy dissipation with high sensitivity using an impedance analyzer. This impedance QCM measures frequency shifts and resistance changes of sensing quartz crystals very stable, accurately, and calibrated, thus yielding quantitative information on mass changes and dissipation. Resistance changes below 0.3 Ω were measured with corresponding dissipation values of 0.01 µU (micro dissipation units). The broadband impedance capabilities allow measurements between 20 Hz and 120 MHz including higher harmonic modes of up to 11th order for a 10 MHz fundamental resonance frequency quartz crystal. We demonstrate the adsorbed mass, calibrated resistance, and quantitative dissipation measurements on two biological systems including the high affinity based avidin-biotin interaction and nano-assemblies of polyelectrolyte layers. The binding affinity of a protein-antibody interaction was determined. The impedance QCM is a versatile and simple method for accurate and calibrated resistance and dissipation measurements with broadband measurement capabilities for higher harmonics measurements.

Indexed as

Biosensing TechniquesElectric ImpedanceQuartz Crystal Microbalance TechniquesCalibrationElectrolytesElectrolytesbiosensingdissipationhigher harmonicsimpedance analysisquartz crystal microbalance

Identifiers

PMID27231946
PMCPMC4931483
OpenAlexW2403837544

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.