Evidence map›Paper›PMID 27231871›Full record

ArticlePloS one2016

A Dosimetric Study of Using Fixed-Jaw Volumetric Modulated Arc Therapy for the Treatment of Nasopharyngeal Carcinoma with Cervical Lymph Node Metastasis.

Wu-Zhe Zhang, Jia-Yang Lu, Jian-Zhou Chen, Tian-Tian Zhai, Bao-Tian Huang, De-Rui Li, Chuang-Zhen Chen

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Wu-Zhe ZhangDepartment of Radiation Oncology, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China.
Jia-Yang LuDepartment of Radiation Oncology, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China.
Jian-Zhou ChenDepartment of Radiation Oncology, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China.
Tian-Tian ZhaiDepartment of Radiation Oncology, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China.
Bao-Tian HuangDepartment of Radiation Oncology, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China.
De-Rui LiDepartment of Radiation Oncology, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China.
Chuang-Zhen ChenDepartment of Radiation Oncology, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China.
Cancer Hospital of Shantou University Medical College · CNShantou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo study the dosimetric difference between fixed-jaw volumetric modulated radiotherapy (FJ-VMAT) and large-field volumetric modulated radiotherapy (LF-VMAT) for nasopharyngeal carcinoma (NPC) with cervical lymph node metastasis.

methodsComputed tomography (CT) datasets of 10 NPC patients undergoing chemoradiotherapy were used to generate LF-VMAT and FJ-VMAT plans in the Eclipse version 10.0 treatment planning system. These two kinds of plans were then compared with respect to planning-target-volume (PTV) coverage, conformity index (CI), homogeneity index (HI), organ-at-risk sparing, monitor units (MUs) and treatment time (TT).

resultsThe FJ-VMAT plans provided lower D2% of PGTVnd (PTV of lymph nodes), PTV1 (high-risk PTV) and PTV2 (low-risk PTV) than did the LF-VMAT plans, whereas no significant differences were observed in PGTVnx (PTV of primary nasopharyngeal tumor). The FJ-VMAT plans provided lower doses delivered to the planning organ at risk (OAR) volumes (PRVs) of both brainstem and spinal cord, both parotid glands and normal tissue than did the LF-VMAT plans, whereas no significant differences were observed with respect to the oral cavity and larynx. The MUs of the FJ-VMAT plans (683 ± 87) were increased by 22% ± 12% compared with the LF-VMAT plans (559 ± 62). In terms of the TT, no significant difference was found between the two kinds of plans.

conclusionsFJ-VMAT was similar or slightly superior to LF-VMAT in terms of PTV coverage and was significantly superior in terms of OAR sparing, at the expense of increased MUs.

Indexed as

AdultAgedCarcinomaFemaleHumansLymphatic MetastasisMaleMiddle AgedNasopharyngeal CarcinomaNasopharyngeal NeoplasmsOrgans at RiskRadiometryRadiotherapy, Intensity-ModulatedRadiotherapy Planning, Computer-AssistedYoung Adult

Identifiers

PMID27231871
PMCPMC4883768
OpenAlexW2402768794

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.