Evidence map›Paper›PMID 27231718›Full record

ArticleACS infectious diseases2016

Cell-Envelope Remodeling as a Determinant of Phenotypic Antibacterial Tolerance in

Gérald Larrouy-Maumus, Leonardo B Marino, Ashoka V R Madduri, T J Ragan, Debbie M Hunt, Lucrezia Bassano, Maximiliano G Gutierrez, D Branch Moody, Fernando R Pavan, Luiz Pedro S de Carvalho

Open access · hybridAbstract read
In one paragraph

Article in ACS infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 53 citations in OpenAlex.

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  10. Beyond antibiotic resistance: thebioRxiv : the preprint server for biology · 2023
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  16. Understanding the contribution of metabolism toFrontiers in cellular and infection microbiology · 2022
    Review
  17. Unraveling the mechanisms of intrinsic drug resistance inFrontiers in cellular and infection microbiology · 2022
    Review
  18. Article
  19. Article
  20. The Phosphatidyl-Journal of bacteriology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Gérald Larrouy-MaumusMycobacterial Metabolism and Antibiotic Research Laboratory and Host-Pathogen Interactions in Tuberculosis Laboratory, The Francis Crick Institute, Mill Hill Laboratory, London NW7 1AA, United Kingdom; Laboratory of Chemical Biology of Tuberculosis Pathogenesis, MRC Centre for Molecular Bacteriology and Infection, Imperial College London, Kensington, London SW7 2DD, United Kingdom.
Leonardo B MarinoMycobacterial Metabolism and Antibiotic Research Laboratory and Host-Pathogen Interactions in Tuberculosis Laboratory, The Francis Crick Institute, Mill Hill Laboratory, London NW7 1AA, United Kingdom; School of Pharmaceutical Sciences, São Paulo State University (UNESP), 4801-902 Araraquara, SP, Brazil.
Ashoka V R MadduriDivision of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School , Boston, Massachusetts 02115, United States.
T J RaganMycobacterial Metabolism and Antibiotic Research Laboratory and Host-Pathogen Interactions in Tuberculosis Laboratory, The Francis Crick Institute , Mill Hill Laboratory, London NW7 1AA, United Kingdom.
Debbie M HuntMycobacterial Metabolism and Antibiotic Research Laboratory and Host-Pathogen Interactions in Tuberculosis Laboratory, The Francis Crick Institute , Mill Hill Laboratory, London NW7 1AA, United Kingdom.
Lucrezia BassanoLaboratory of Chemical Biology of Tuberculosis Pathogenesis, MRC Centre for Molecular Bacteriology and Infection, Imperial College London , Kensington, London SW7 2DD, United Kingdom.
Maximiliano G GutierrezMycobacterial Metabolism and Antibiotic Research Laboratory and Host-Pathogen Interactions in Tuberculosis Laboratory, The Francis Crick Institute , Mill Hill Laboratory, London NW7 1AA, United Kingdom.
D Branch MoodyDivision of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School , Boston, Massachusetts 02115, United States.
Fernando R PavanSchool of Pharmaceutical Sciences, São Paulo State University (UNESP) , 4801-902 Araraquara, SP, Brazil.
Luiz Pedro S de CarvalhoMycobacterial Metabolism and Antibiotic Research Laboratory and Host-Pathogen Interactions in Tuberculosis Laboratory, The Francis Crick Institute , Mill Hill Laboratory, London NW7 1AA, United Kingdom.
The Francis Crick Institute · GBImperial College London · GBUniversidade Estadual Paulista (Unesp) · BRBrigham and Women's Hospital · USHarvard University · US

Funding

Metabolomics Core U19AI111224 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI BASARABA, RANDALL J, MURRAY, MEGAN B · 2015 to 2021
$20.4M
T cell response to CDI-restricted lipids in tuberculosisR01AI049313 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI MOODY, DAVID BRANCH · 2001 to 2025
$10.6M
Remodeling of the M. tuberculosis cell wall during infectionR01AI071155 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI MOODY, DAVID BRANCH · 2006 to 2010
$2.1M
Medical Research Council MC_U117533887Medical Research Council MC_UP_1202/11Medical Research Council MC_UP_A253_1111Medical Research Council MR/J006874/1NIAID NIH HHS R01 AI049313NIAID NIH HHS R01 AI071155NIAID NIH HHS U19 AI111224Wellcome Trust
6 · The paper itself

Abstract

The mechanisms that lead to phenotypic antibacterial tolerance in bacteria remain poorly understood. We investigate whether changes in NaCl concentration toward physiologically higher values affect antibacterial efficacy against

Indexed as

cell envelope remodelinglipidsMycobacterium tuberculosisosmolarityphenotypic antibacterial tolerance

Identifiers

PMID27231718
PMCPMC4877114
OpenAlexW2322566652

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.