ArticleAnnals of clinical and translational neurology2016
Diagnostic delay in progressive multifocal leukoencephalopathy.
Article in Annals of clinical and translational neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Natalizumab-Related Progressive Multifocal Leukoencephalopathy in Multiple Sclerosis: Findings from an Italian Independent Registry.PloS one · 2016Trial
- Rapid onset of neurological symptoms in an HIV-positive patient with progressive multifocal leukoencephalopathy: a case report.Annals of medicine and surgery (2012) · 2025Article
- Progressive multifocal leukoencephalopathy in rheumatoid arthritis and biological therapies: a case report and review of the literature.Journal of medical case reports · 2025Review
- Disproportionality analysis of drug-associated progressive multifocal leukoencephalopathy: roles of underlying diseases and immunomodulatory therapies in FAERS.Frontiers in immunology · 2025Article
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- Diagnostic delays of periodontitis and associated factors: a cross-sectional study.Clinical oral investigations · 2024Article
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- Article
- Progressive multifocal leukoencephalopathy: A 25-year retrospective cohort study.Neurology(R) neuroimmunology & neuroinflammation · 2019Observational
- The Incidence and Predisposing Factors of John Cunningham Virus-Induced Progressive Multifocal Leukoencephalopathy in Southern Finland: A Population-Based Study.Open forum infectious diseases · 2019Article
- Neurologic Complications of Human Immunodeficiency Virus Infection.Continuum (Minneapolis, Minn.) · 2018Review
- PML-IRIS in an HIV-2-infected patient presenting as Bell's palsy.Journal of neurovirology · 2017Article
- Toward Understanding the When and Why of Human Immunodeficiency Virus-Associated Stroke.The Journal of infectious diseases · 2017Article
- Progressive multifocal leukoencephalopathy after heart transplantation: 4 years of clinically stable infection on low-dose immunosuppressive therapy.Oxford medical case reports · 2017Article
- Progressive multifocal leukoencephalopathy - a diagnostic guide for the clinical neurologist.Frontiers in neurologyReview
- Progressive multifocal leukoencephalopathy in a patient with relapsed chronic lymphocytic leukemia treated with Ibrutinib.Hematology, transfusion and cell therapyArticle
- Progressive multifocal leukoencephalopathy: a challenging diagnosis established at autopsy.Autopsy & case reportsArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
We investigated delay in diagnosing progressive multifocal leukoencephalopathy (PML). The median time from initial symptom to diagnosis was 74 days (range 1-1643) in 111 PML patients seen at our institution from 1993 to 2015. Another diagnosis was considered before PML in nearly two-thirds, and more than three-quarters of patients suffered from diagnostic delay greater than 1 month, irrespective of their underlying immunosuppressive condition. Extended diagnostic delay occurred more frequently in patients with possible PML, and among HIV (+) patients with higher CD4(+) T-cell counts at symptom onset. Prompt diagnosis may improve survival of PML in so far as immune reconstitution can be effected, and prevent unnecessary interventions.
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Registered trials
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