Evidence map›Paper›PMID 27231701›Full record

ArticleEndocrine disruptors (Austin, Tex.)

Assessing Human Health Risk to Endocrine Disrupting Chemicals: a Focus on Prenatal Exposures and Oxidative Stress.

Kari Neier, Elizabeth H Marchlewicz, Dana C Dolinoy, Vasantha Padmanabhan

Abstract read
In one paragraph

Article in Endocrine disruptors (Austin, Tex.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  15. Oxysterols Profile in Zebrafish Embryos Exposed to Triclocarban and Propylparaben-A Preliminary Study.International journal of environmental research and public health · 2022
    Article
  16. Mitochondrial Epigenetics and Environmental Health: Making a Case for Endocrine Disrupting Chemicals.Toxicological sciences : an official journal of the Society of Toxicology · 2020
    Review
  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kari NeierDepartment of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan 48109.
Elizabeth H MarchlewiczDepartment of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan 48109.
Dana C DolinoyDepartment of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan 48109; Department of Nutritional Sciences, University of Michigan, Ann Arbor, Michigan 48109.
Vasantha PadmanabhanDepartment of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan 48109; Department of Pediatrics, University of Michigan, Ann Arbor 48109.

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
Strategic Vision & Impact on Environmental HealthP30ES017885 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Dana Dolinoy · 2011 to 2026
$21.3M
ENVIRONMENTAL TOXICOLOGY PRE/POST DOCTORAL RES.TRAININGT32ES007062 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Justin Adam Colacino · 1985 to 2026
$10.5M
Project 3: Developmental Exposures and Diet: Epigenetics of Metabolic SyndromeP01ES022844 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PADMANABHAN, VASANTHA, PETERSON, KAREN EILEEN · 2013 to 2018
$3.9M
Career Training in Reproductive BiologyT32HD079342 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Suzanne M MOENTER · 2014 to 2026
$2.3M
In Utero Exposure to Bisphenol A: Effects on the Fetal EpigenomeR01ES017524 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DOLINOY, DANA · 2009 to 2013
$2.2M
Bisphenol-A and Reproductive DysfunctionR01ES016541 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PADMANABHAN, VASANTHA · 2009 to 2013
$2.0M
Endocrine Disruptors and Fetal DevelopmentR01ES017005 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PADMANABHAN, VASANTHA · 2009 to 2010
$998k
NICHD NIH HHS T32 HD079342NIDDK NIH HHS P30 DK020572NIEHS NIH HHS P01 ES022844NIEHS NIH HHS P30 ES017885NIEHS NIH HHS R01 ES016541NIEHS NIH HHS R01 ES017005NIEHS NIH HHS R01 ES017524NIEHS NIH HHS T32 ES007062
6 · The paper itself

Abstract

Understanding the health risk posed by endocrine disrupting chemicals (EDCs) is a challenge that is receiving intense attention. The following study criteria should be considered to facilitate risk assessment for exposure to EDCs: 1) characterization of target health outcomes and their mediators, 2) study of exposures in the context of critical periods of development, 3) accurate estimates of human exposures and use of human-relevant exposures in animal studies, and 4) cross-species comparisons. In this commentary, we discuss the importance and relevance of each of these criteria in studying the effects of prenatal exposure to EDCs. Our discussion focuses on oxidative stress as a mediator of EDC-related health effects due to its association with both EDC exposure and health outcomes. Our recent study (Veiga-Lopez et al. 2015)

Indexed as

EDCsorganizational effectsoxidative stressprenatal programmingrisk assessment

Identifiers

PMID27231701
PMCPMC4876868

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.