ArticleBiomedical optics express2016
Miniature fiber-optic multiphoton microscopy system using frequency-doubled femtosecond Er-doped fiber laser.
Article in Biomedical optics express, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Prognostic significance of collagen signatures in pancreatic ductal adenocarcinoma obtained from second-harmonic generation imaging.BMC cancer · 2024Article
- Exploration of the relationship between tumor-infiltrating lymphocyte score and histological grade in breast cancer.BMC cancer · 2024Article
- Two-Photon Endoscopy: State of the Art and Perspectives.Molecular imaging and biology · 2023Review
- Multiphoton excitation imaging via an actively mode-locked tunable fiber-cavity SOA laser around 800 nm.Biomedical optics express · 2022Article
- Single-Pixel MEMS Imaging Systems.Micromachines · 2020Review
- Miniaturized multimodal multiphoton microscope for simultaneous two-photon and three-photon imaging with a dual-wavelength Er-doped fiber laser.Biomedical optics express · 2020Article
- Multimodal imaging platform for optical virtual skin biopsy enabled by a fiber-based two-color ultrafast laser source.Biomedical optics express · 2019Article
- MEMS Actuators for Optical Microendoscopy.Micromachines · 2019Review
- Compact diode laser source for multiphoton biological imaging.Biomedical optics express · 2017Article
- Design of a fiber-optic multiphoton microscopy handheld probe.Biomedical optics express · 2016Article
- Handheld nonlinear microscope system comprising a 2 MHz repetition rate, mode-locked Yb-fiber laser forBiomedical optics express · 2016Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report on a miniature fiber-optic multiphoton microscopy (MPM) system based on a frequency-doubled femtosecond Er-doped fiber laser. The femtosecond pulses from the laser source are delivered to the miniature fiber-optic probe at 1.58 µm wavelength, where a standard single mode fiber is used for delivery without the need of free-space dispersion compensation components. The beam is frequency-doubled inside the probe by a periodically poled MgO:LiNbO3 crystal. Frequency-doubled pulses at 786 nm with a maximum power of 80 mW and a pulsewidth of 150 fs are obtained and applied to excite intrinsic signals from tissues. A MEMS scanner, a miniature objective, and a multimode collection fiber are further used to make the probe compact. The miniature fiber-optic MPM system is highly portable and robust. Ex vivo multiphoton imaging of mammalian skins demonstrates the capability of the system in imaging biological tissues. The results show that the miniature fiber-optic MPM system using frequency-doubled femtosecond fiber laser can potentially bring the MPM imaging for clinical applications.
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