Evidence map›Paper›PMID 27231590›Full record

ArticleBiomedical optics express2016

In vivo Raman measurement of levofloxacin lactate in blood using a nanoparticle-coated optical fiber probe.

Shupeng Liu, Ming Rong, Heng Zhang, Na Chen, Fufei Pang, Zhenyi Chen, Tingyun Wang, Jianshe Yan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shupeng LiuKey Laboratory of Specialty Fiber Optics and Optical Access Networks, School of Communication and Information, Engineering, Shanghai University, 333 Nanchen Road, Shanghai 200444, China; liusp@shu.edu.cn.
Ming RongKey Laboratory of Specialty Fiber Optics and Optical Access Networks, School of Communication and Information, Engineering, Shanghai University, 333 Nanchen Road, Shanghai 200444, China.
Heng ZhangKey Laboratory of Specialty Fiber Optics and Optical Access Networks, School of Communication and Information, Engineering, Shanghai University, 333 Nanchen Road, Shanghai 200444, China.
Na ChenKey Laboratory of Specialty Fiber Optics and Optical Access Networks, School of Communication and Information, Engineering, Shanghai University, 333 Nanchen Road, Shanghai 200444, China; na.chen@shu.edu.cn.
Fufei PangKey Laboratory of Specialty Fiber Optics and Optical Access Networks, School of Communication and Information, Engineering, Shanghai University, 333 Nanchen Road, Shanghai 200444, China.
Zhenyi ChenKey Laboratory of Specialty Fiber Optics and Optical Access Networks, School of Communication and Information, Engineering, Shanghai University, 333 Nanchen Road, Shanghai 200444, China.
Tingyun WangKey Laboratory of Specialty Fiber Optics and Optical Access Networks, School of Communication and Information, Engineering, Shanghai University, 333 Nanchen Road, Shanghai 200444, China.
Jianshe YanShanghai Institute of Immunology, Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, China; yanjianshe@sjtu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Monitoring drug concentrations in vivo is very useful for adjusting a drug dosage during treatment and for drug research. Specifically, cutting-edge "on-line" drug research relies on knowing how drugs are metabolized or how they interact with the blood in real-time. Thus, this study explored performing in vivo Raman measurements of the model drug levofloxacin lactate in the blood using a nanoparticle-coated optical fiber probe (optical fiber nano-probe). The results show that we were able to measure real-time changes in the blood concentration of levofloxacin lactate, suggesting that this technique could be helpful for performing drug analyses and drug monitoring in a clinical setting without repeatedly withdrawing blood from patients.

Indexed as

(170.1470) Blood or tissue constituent monitoring(170.5660) Raman spectroscopy(290.5880) Scattering, rough surfaces

Identifiers

PMID27231590
PMCPMC4866457

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.