ArticleBiomedical optics express2016
Fast blood flow monitoring in deep tissues with real-time software correlators.
Article in Biomedical optics express, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
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Who cites it
76 citing papers in PubMed.
- Cerebral Blood Flow Response During Bolus Normal Saline Infusion After Ischemic Stroke.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2019Trial
- Effects of exercise training on calf muscle oxygen extraction and blood flow in patients with peripheral artery disease.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Trial
- Compact FPGA-based software correlator for real-time blood flow measurement with diffuse correlation spectroscopy.Biomedical optics express · 2026Article
- CoMind R1: a time-resolved interferometric optical neuromonitoring system for pulsatile cerebral blood flow measurement at late times-of-flight.Neurophotonics · 2026Article
- Depth-sensitive cerebral blood flow and low-frequency oscillations for consciousness assessment using time-domain diffuse correlation spectroscopy.Neurophotonics · 2026Article
- Characterization of a fiber-coupled SPAD camera system for deep-tissue blood-flow measurement using diffuse correlation spectroscopy.Biomedical optics express · 2026Article
- Comparing multi- and single-exposure speckle contrast optical spectroscopy methods as estimators of blood flow in the diffuse regime.Journal of biomedical optics · 2026Article
- Reproducibility of a time-resolved NIRS, multidistance diffuse correlation spectroscopy system: towards noninvasive longitudinal neuromonitoring.Neurophotonics · 2026Article
- Approaches for modelling autocorrelation function and data processing in time-domain diffuse correlation spectroscopy.Biomedical optics express · 2025Article
- Comparison of diffuse correlation spectroscopy analytical models for cerebral blood flow measurements.Journal of biomedical optics · 2025Article
- On-skin, micro-objective enabled camera module for speckle contrast optical spectroscopy/tomography.Biomedical optics express · 2025Article
- Affordable miniaturized speckle contrast diffuse correlation tomography device for depth-sensitive mapping of cerebral blood flow in rodents.Journal of biomedical optics · 2025Article
- Comparison of diffuse correlation spectroscopy, interferometric diffusing wave spectroscopy, and speckle contrast optical spectroscopy for blood flow monitoring.Neurophotonics · 2025Article
- Cerebral blood flow monitoring using a deep learning implementation of the two-layer diffuse correlation spectroscopy analytical model with a 512 × 512 SPAD array.Neurophotonics · 2025Article
- Article
- Proof of concept validation of bioresorbable optical fibers for diffuse correlation spectroscopy.Biomedical optics express · 2024Article
- ATLAS: a large array, on-chip compute SPAD camera for multispeckle diffuse correlation spectroscopy.Biomedical optics express · 2024Article
- Microvascular reperfusion during endovascular therapy: the balance of supply and demand.Journal of neurointerventional surgery · 2024Article
- Modified Beer-Lambert algorithm to measure pulsatile blood flow, critical closing pressure, and intracranial hypertension.Biomedical optics express · 2024Article
- A Device-on-Chip Solution for Real-Time Diffuse Correlation Spectroscopy Using FPGA.Biosensors · 2024Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
We introduce, validate and demonstrate a new software correlator for high-speed measurement of blood flow in deep tissues based on diffuse correlation spectroscopy (DCS). The software correlator scheme employs standard PC-based data acquisition boards to measure temporal intensity autocorrelation functions continuously at 50 - 100 Hz, the fastest blood flow measurements reported with DCS to date. The data streams, obtained in vivo for typical source-detector separations of 2.5 cm, easily resolve pulsatile heart-beat fluctuations in blood flow which were previously considered to be noise. We employ the device to separate tissue blood flow from tissue absorption/scattering dynamics and thereby show that the origin of the pulsatile DCS signal is primarily flow, and we monitor cerebral autoregulation dynamics in healthy volunteers more accurately than with traditional instrumentation as a result of increased data acquisition rates. Finally, we characterize measurement signal-to-noise ratio and identify count rate and averaging parameters needed for optimal performance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.