ArticleBiomedical optics express2016
Sensitivity of laser speckle contrast imaging to flow perturbations in the cortex.
Article in Biomedical optics express, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Minimally Invasive Bowel Cancer Detection through Vibrating Microrobot-Induced Elastography.Advanced intelligent systems (Weinheim an der Bergstrasse, Germany) · 2025Article
- Improvements and validation of spatiotemporal speckle correlation model for rolling shutter speckle imaging.Biomedical optics express · 2024Article
- Dynamic light scattering and laser speckle contrast imaging of the brain: theory of the spatial and temporal statistics of speckle pattern evolution.Biomedical optics express · 2024Article
- Wide dynamic range measurement of blood flowJournal of biomedical optics · 2024Article
- Choosing a polarisation configuration for dynamic light scattering and laser speckle contrast imaging.Biomedical optics express · 2024Article
- Quasi-analytic solution for real-time multi-exposure speckle imaging of tissue perfusion.Biomedical optics express · 2023Article
- A quasi-analytic solution for real-time multi-exposure speckle imaging of tissue perfusion.bioRxiv : the preprint server for biology · 2023Article
- Using pressure-driven flow systems to evaluate laser speckle contrast imaging.Journal of biomedical optics · 2023Article
- Direct characterization of tissue dynamics with laser speckle contrast imaging.Biomedical optics express · 2022Article
- High-resolution three-dimensional blood flow tomography in the subdiffuse regime using laser speckle contrast imaging.Journal of biomedical optics · 2022Article
- Article
- Choosing a model for laser speckle contrast imaging.Biomedical optics express · 2021Article
- Dynamic light scattering imaging.Science advances · 2020Article
- Effect of vascular structure on laser speckle contrast imaging.Biomedical optics express · 2020Article
- Contribution of speckle noise in near-infrared spectroscopy measurements.Journal of biomedical optics · 2019Article
- Poster Viewing Sessions PB01-B01 to PB03-V09.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Article
- Interstitial imaging with multiple diffusive reflectance spectroscopy projections forNeurophotonics · 2019Article
- Multiple speckle exposure imaging for the study of blood flow changes induced by functional activation of barrel cortex and olfactory bulb in mice.Neurophotonics · 2019Article
- Wearable speckle plethysmography (SPG) for characterizing microvascular flow and resistance.Biomedical optics express · 2018Article
- Article
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4 authors.
Funding
Abstract
Laser speckle contrast imaging has become a ubiquitous tool for imaging blood flow in a variety of tissues. However, due to its widefield imaging nature, the measured speckle contrast is a depth integrated quantity and interpretation of baseline values and the depth dependent sensitivity of those values to changes in underlying flow has not been thoroughly evaluated. Using dynamic light scattering Monte Carlo simulations, the sensitivity of the autocorrelation function and speckle contrast to flow changes in the cerebral cortex was extensively examined. These simulations demonstrate that the sensitivity of the inverse autocorrelation time, [Formula: see text], varies across the field of view: directly over surface vessels [Formula: see text] is strongly localized to the single vessel, while parenchymal ROIs have a larger sensitivity to flow changes at depths up to 500 μm into the tissue and up to 200 μm lateral to the ROI. It is also shown that utilizing the commonly used models the relate [Formula: see text] to flow resulted in nearly the same sensitivity to the underlying flow, but fail to accurately relate speckle contrast values to absolute [Formula: see text].
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