ArticleProceedings of the National Academy of Sciences of the United States of America2016
Superresolved multiphoton microscopy with spatial frequency-modulated imaging.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- In vivo three-photon fluorescence imaging of mouse brain vasculature labeled by Evans blue excited at the NIR-III window.Biomedical optics express · 2025Article
- Fortunate molecules boost signal to background ratio and localization precision in correlation based single molecule localization microscopy.Communications biology · 2024Article
- Breaking Abbe's diffraction limit with harmonic deactivation microscopy.Science advances · 2024Article
- Cascaded domain multiphoton spatial frequency modulation imaging.Journal of biomedical optics · 2023Article
- Viewing life without labels under optical microscopes.Communications biology · 2023Review
- Bioimaging with Upconversion Nanoparticles.Advanced photonics research · 2022Article
- Super-resolution re-scan second harmonic generation microscopy.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Compressed sensing in the far-field of the spatial light modulator in high noise conditions.Scientific reports · 2021Article
- Bioinspired caries preventive strategy via customizable pellicles of saliva-derived protein/peptide constructs.Scientific reports · 2021Article
- Article
- Two-dimensional random access multiphoton spatial frequency modulated imaging.Optics express · 2020Article
- Targeting the oral plaque microbiome with immobilized anti-biofilm peptides at tooth-restoration interfaces.PloS one · 2020Article
- Fourier computed tomographic imaging of two dimensional fluorescent objects.APL photonics · 2019Article
- Kilohertz frame-rate two-photon tomography.Nature methods · 2019Article
- Fluorescent coherent diffractive imaging with accelerating light sheets.Optics express · 2019Article
- Improving resolution of second harmonic generation microscopy via scanning structured illumination.Biomedical optics express · 2018Article
- Three-dimensional single-pixel imaging of incoherent light with spatiotemporally modulated illumination.Journal of the Optical Society of America. A, Optics, image science, and vision · 2018Article
- Super-resolution fluorescence microscopy by stepwise optical saturation.Biomedical optics express · 2018Article
- General theoretical treatment of spectral modulation light-labeling spectroscopy.Journal of the Optical Society of America. B, Optical physics · 2016Article
- Simultaneous spatial frequency modulation imaging and micromachining with a femtosecond laser.Optics letters · 2016Article
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Authors and funding
10 authors.
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Abstract
Superresolved far-field microscopy has emerged as a powerful tool for investigating the structure of objects with resolution well below the diffraction limit of light. Nearly all superresolution imaging techniques reported to date rely on real energy states of fluorescent molecules to circumvent the diffraction limit, preventing superresolved imaging with contrast mechanisms that occur via virtual energy states, including harmonic generation (HG). We report a superresolution technique based on spatial frequency-modulated imaging (SPIFI) that permits superresolved nonlinear microscopy with any contrast mechanism and with single-pixel detection. We show multimodal superresolved images with two-photon excited fluorescence (TPEF) and second-harmonic generation (SHG) from biological and inorganic media. Multiphoton SPIFI (MP-SPIFI) provides spatial resolution up to 2η below the diffraction limit, where η is the highest power of the nonlinear intensity response. MP-SPIFI can be used to provide enhanced resolution in optically thin media and may provide a solution for superresolved imaging deep in scattering media.
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