ArticleChinese medical journal2016
Imbalance of Fecal Microbiota at Newly Diagnosed Type 1 Diabetes in Chinese Children.
Article in Chinese medical journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 6 of them syntheses that pooled it.
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Who cites it
56 citing papers in PubMed, 6 syntheses or guidelines pooled it, 90 citations in OpenAlex.
- Meta-Analysis Reveals Compositional and Functional Microbial Changes Associated with Osteoporosis.Microbiology spectrum · 2023Pooled it
- Gut microbiome and blood glucose control in type 1 diabetes: a systematic review.Frontiers in endocrinology · 2023Pooled it
- Reproducible and opposing gut microbiome signatures distinguish autoimmune diseases and cancers: a systematic review and meta-analysis.Microbiome · 2022Pooled it
- Mechanismbased role of the intestinal microbiota in gestational diabetes mellitus: A systematic review and meta-analysis.Frontiers in immunology · 2022Pooled it
- Safety and efficacy of fecal microbiota transplantation for autoimmune diseases and autoinflammatory diseases: A systematic review and meta-analysis.Frontiers in immunology · 2022Pooled it
- Gut Microbiota Profile in Patients with Type 1 Diabetes Based on 16S rRNA Gene Sequencing: A Systematic Review.Disease markers · 2020Pooled it
- The Role of Microbiota in Type 1 Diabetes: Insights into Dysbiosis and Immune Interactions.Nutrients · 2026Review
- Childhood type 1 diabetes mellitus and gut microbiota: from microbiome characteristics to prevention and treatment strategies.Frontiers in cellular and infection microbiology · 2026Review
- Unraveling Type 1 Diabetes: Integrating Microbiome, Metabolomics, and Immunomodulation for Next-Generation Therapies.International journal of molecular sciences · 2025Review
- Review
- The Comparison of the Gut Microbiome Composition, Serum Inflammatory Markers and Faecal Short-Chain Fatty Acids Among Individuals With Type 1 and 2 Diabetes Mellitus With Healthy Controls: A Case-Control Study.Endocrinology, diabetes & metabolism · 2025Article
- Unravelling the Role of Gut and Oral Microbiota in the Pediatric Population with Type 1 Diabetes Mellitus.International journal of molecular sciences · 2024Review
- A comparative study of the gut microbiome in Indian children with type 1 diabetes and healthy controls.Journal of diabetes · 2024Article
- Diabetes and gut microbiome.Frontiers in microbiology · 2024Review
- Research progress in the treatment of an immune system disease-type 1 diabetes-by regulating the intestinal flora with Chinese medicine and food homologous drugs.Bioscience of microbiota, food and health · 2024Review
- Associations of disordered eating with the intestinal microbiota and short-chain fatty acids among young adults with type 1 diabetes.Nutrition, metabolism, and cardiovascular diseases : NMCD · 2023Article
- Functional and metabolic alterations of gut microbiota in children with new-onset type 1 diabetes.Nature communications · 2022Article
- Gut Dysbiosis and Fecal Microbiota Transplantation in Autoimmune Diseases.International journal of molecular sciences · 2022Review
- Low-dose IL-2 shapes a tolerogenic gut microbiota that improves autoimmunity and gut inflammation.JCI insight · 2022Article
- High-risk genotypes for type 1 diabetes are associated with the imbalance of gut microbiome and serum metabolites.Frontiers in immunology · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent studies have indicated that an imbalance of gut microbiota is associated with the development of type 1 diabetes mellitus (T1DM) and there is no literature regarding it in Chinese children yet. The aim of this study was to evaluate the alteration of gut microbiota between children with newly diagnosed T1DM and healthy controls and to determine if gut microbiota could partly explain the etiology of this disease.
methodsA case-control study was carried out with 15 children with T1DM and 15 healthy children. The fecal bacteria composition was investigated by high-throughput sequencing of the V3-V4 region of the 16S rDNA gene and analyzed by the estimators of community richness (Chao) indexes.
resultsThere was a notable lower richness of fecal bacteria in T1DM group than controls (156.53 ± 36.96 vs. 130.0 ± 32.85, P = 0.047). At the genus level, the composition of Blautia was increased in T1DM group than control group whereas the composition of Haemophilus, Lachnospira, Dialister, and Acidaminococcus was decreased. In addition, we found that the percentage of Blautia was correlated positively with HbA1c (ρ = 0.40, P = 0.031), the numbers of T1DM autoantibodies (ρ = 0.42, P = 0.023), and the titers of tyrosine phosphatase autoantibodies (IA-2) (ρ = 0.82, P = 0.000) in the study.
conclusionsThis study showed that gut microbiota was associated with the development of T1DM by affecting the autoimmunity, and the results suggested a potential therapy for T1DM via modulating the gut microbiota.
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