Evidence map›Paper›PMID 27231145›Full record

ArticleInnate immunity2016

Type I interferon licenses enhanced innate recognition and transcriptional responses to Franciscella tularensis live vaccine strain.

Katharina Richard, Stefanie N Vogel, Darren J Perkins

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Innate immunity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. The immune response toFrontiers in microbiology · 2025
    Review
  3. Review
  4. Review
  5. Autocrine-paracrine prostaglandin ENature immunology · 2018
    Article
  6. Innate Immune Recognition: Implications for the Interaction ofFrontiers in cellular and infection microbiology · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Katharina RichardDepartment of Microbiology and Immunology, University of Maryland, Baltimore (UMB), School of Medicine, Baltimore, MD, USA.
Stefanie N VogelDepartment of Microbiology and Immunology, University of Maryland, Baltimore (UMB), School of Medicine, Baltimore, MD, USA svogel@som.umaryland.edu.
Darren J PerkinsDepartment of Microbiology and Immunology, University of Maryland, Baltimore (UMB), School of Medicine, Baltimore, MD, USA.
University of Maryland, Baltimore · US

Funding

Signaling Pathways in Innate ImmunityT32AI095190 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI Stefanie N. Vogel · 2012 to 2026
$4.7M
Differentiative Signals for Macrophage ActivationR56AI018797 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI VOGEL, STEFANIE N. · 2015 to 2015
$506k
NIAID NIH HHS R56 AI018797NIAID NIH HHS T32 AI095190
6 · The paper itself

Abstract

The innate inflammatory response to Francisella tularensis (Ft) in macrophages is significantly governed by the expression of type I interferon (IFN). Previously, the proteolytic processing and maturation of pro-IL-1β protein was shown to depend upon type I IFN expression. We show in this report that paracrine type I IFN can profoundly enhance innate recognition and TLR-dependent transcriptional responses to Ft infection upstream of its role in inflammasome regulation in both primary human monocyte-derived macrophages and primary murine peritoneal macrophages but not murine bone marrow-derived macrophages. This type I IFN-enhanced response is synergistic with TLR2 transcriptional responses, partially TLR2-independent, but strictly MyD88-dependent.

Indexed as

AnimalsFrancisella tularensisHumansImmunity, InnateInflammasomesInterferon-betaInterleukin-1betaMacrophagesMacrophages, PeritonealMiceMice, Inbred C57BLMyeloid Differentiation Factor 88Organ SpecificityRAW 264.7 CellsToll-Like Receptor 2Transcription, GeneticInflammasomesInterferon-betaInterleukin-1betaMyeloid Differentiation Factor 88Tlr2 protein, mouseToll-Like Receptor 2Francisella tularensis LVSIFN-βmacrophageTLR2type I interferon

Identifiers

PMID27231145
PMCPMC4955828
OpenAlexW2405614697

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.