ArticleOrganogenesis2016
Vitamin C promotes the proliferation of human adipose-derived stem cells via p53-p21 pathway.
Article in Organogenesis, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Trial
- L-Ascorbic Acid 2-Phosphate-Releasing Poly(trimethylene carbonate) Increases Cell Proliferation and Collagen Production: A Novel Material for Pelvic Organ Prolapse Tissue Engineering.Tissue engineering and regenerative medicine · 2026Article
- Injectable hydrogels for bone regeneration: from materials design to clinical translation.RSC advances · 2026Review
- Vitamin C and N-acetylcysteine promote bovine adipose-derived mesenchymal stem cell proliferation and differentiation via Akt/mTOR/P70S6K signalling pathway for cultured meat production.Animal bioscience · 2025Article
- L-Ascorbic Acid (LAA) Supplementation as a Potential Treatment for Skin Aging: Regulation of Adipose Tissue Mesenchymal Stem Cells (AT-MSCs) Protein Secretion.Current issues in molecular biology · 2025Article
- Integration of Untargeted Metabolomics with Transcriptomics Provides Insights into Beauvericin Biosynthesis inJournal of fungi (Basel, Switzerland) · 2022Article
- New Translational Trends in Personalized Medicine: Autologous Peripheral Blood Stem Cells and Plasma for COVID-19 Patient.Journal of personalized medicine · 2022Article
- Cell penetration and chondrogenic differentiation of human adipose derived stem cells on 3D scaffold.Future science OA · 2021Article
- Unraveling the Developmental Roadmap toward Human Brown Adipose Tissue.Stem cell reports · 2021Article
- Epigenetic Regulation of Genomic Stability by Vitamin C.Frontiers in genetics · 2021Review
- Accelerated corneal endothelial cell loss in two patients with granulomatosis with polyangiitis following phacoemulsification.BMC ophthalmology · 2020Article
- Vitamin C improves the therapeutic potential of human amniotic epithelial cells in premature ovarian insufficiency disease.Stem cell research & therapy · 2020Article
- Redox Homeostasis Plays Important Roles in the Maintenance of the Drosophila Testis Germline Stem Cells.Stem cell reports · 2017Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although adipose-derived stem cells (ADSCs) have demonstrated a promising potential for the applications of cell-based therapy and regenerative medicine, excessive reactive oxygen species (ROS) are harmful to ADSCs cell survival and proliferation. Vitamin C is an important antioxidant, and is often added into culture media as an essential micronutrient. However, its roles on the proliferation of human ADSCs have not been studied. Therefore, in this study, human ADSCs were isolated, and detected by flow cytometry for the analysis of their cell surface antigens. Cell proliferation and cell cycle progression were measured with cell counting kit-8 assay and flow cytometry, respectively. Western blotting was used to detect the expression levels of cyclin E1, p53, p21, and CDK2 proteins. The effect of vitamin C pretreatment on the production of hydrogen peroxide (H
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