ArticleJournal of innate immunity2016
The POU/Oct Transcription Factor Pdm1/nub Is Necessary for a Beneficial Gut Microbiota and Normal Lifespan of Drosophila.
Article in Journal of innate immunity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 50 citations in OpenAlex.
- A non-transcriptional mitotic function of POU/Oct factors ensures spindle assembly and chromosome segregation.Journal of cell science · 2026Article
- Chronic intestinal immune activation reveals separable impacts of inflammation and barrier loss on hallmarks of ageing.PloS one · 2026Article
- Microbiome transplants may not improve health and longevity in Drosophila melanogaster.Biology open · 2025Article
- Article
- Intestinal barrier dysfunction: an evolutionarily conserved hallmark of aging.Disease models & mechanisms · 2023Review
- Article
- Review
- The Role of Microbiota inFrontiers in aging · 2022Review
- Regulatory regions in natural transposable element insertions drive interindividual differences in response to immune challenges in Drosophila.Genome biology · 2021Article
- Stop codon readthrough alters the activity of a POU/Oct transcription factor during Drosophila development.BMC biology · 2021Article
- The Role of Gut Microbiota in Aging and Aging Related Neurodegenerative Disorders: Insights fromLife (Basel, Switzerland) · 2021Review
- Effect of Nora virus infection on native gut bacterial communities ofAIMS microbiology · 2021Article
- Immune challenge reduces gut microbial diversity and triggers fertility-dependent gene expression changes in a social insect.BMC genomics · 2020Article
- Article
- Drosophila melanogaster establishes a species-specific mutualistic interaction with stable gut-colonizing bacteria.PLoS biology · 2018Article
- The POU/Oct Transcription Factor Nubbin Controls the Balance of Intestinal Stem Cell Maintenance and Differentiation by Isoform-Specific Regulation.Stem cell reports · 2018Article
- Nubbin isoform antagonism governs Drosophila intestinal immune homeostasis.PLoS pathogens · 2018Article
- Journal of Innate Immunity Ten Years Later.Journal of innate immunity · 2018Article
- Role of gut microbiota in aging-related health decline: insights from invertebrate models.Cellular and molecular life sciences : CMLS · 2018Review
- Interaction Between Familial Transmission and a Constitutively Active Immune System Shapes Gut Microbiota inGenetics · 2017Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Maintenance of a stable gut microbial community relies on a delicate balance between immune defense and immune tolerance. We have used Drosophila to study how the microbial gut flora is affected by changes in host genetic factors and immunity. Flies with a constitutively active gut immune system, due to a mutation in the POU transcriptional regulator Pdm1/nubbin (nub) gene, had higher loads of bacteria and a more diverse taxonomic composition than controls. In addition, the microbial composition shifted considerably during the short lifespan of the nub1 mutants. This shift was characterized by a loss of relatively few OTUs (operational taxonomic units) and a remarkable increase in a large number of Acetobacter spp. and Leuconostoc spp. Treating nub1 mutant flies with antibiotics prolonged their lifetime survival by more than 100%. Immune gene expression was also persistently high in the presence of antibiotics, indicating that the early death was not a direct consequence of an overactive immune defense but rather an indirect consequence of the microbial load and composition. Thus, changes in host genotype and an inability to regulate the normal growth and composition of the gut microbiota leads to a shift in the microbial community, dysbiosis and early death.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.