Evidence map›Paper›PMID 27230966›Full record

ArticleThe Journal of physiology2016

Systemic leukotriene B

Paul J Marvar, Emma B Hendy, Thomas D Cruise, Dawid Walas, Danielle DeCicco, Rajanikanth Vadigepalli, James S Schwaber, Hidefumi Waki, David Murphy, Julian F R Paton

Open access · greenAbstract read
In one paragraph

Article in The Journal of physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Renal denervation based on experimental rationale.Hypertension research : official journal of the Japanese Society of Hypertension · 2021
    Review
  5. Review
  6. Article
  7. Inflammatory pathways are central to posterior cerebrovascular artery remodelling prior to the onset of congenital hypertension.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019
    Article
  8. Article
  9. Article
  10. Article
  11. Study on the Antihypertensive Mechanism ofEvidence-based complementary and alternative medicine : eCAM · 2019
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Paul J MarvarDepartment of Pharmacology and Physiology Washington, The George Washington University School of Medical and Health Sciences, Washington, DC, USA.
Emma B HendySchool of Physiology, Pharmacology & Neuroscience, Medical Sciences, University of Bristol, Bristol, BS8 1TD, UK.
Thomas D CruiseSchool of Physiology, Pharmacology & Neuroscience, Medical Sciences, University of Bristol, Bristol, BS8 1TD, UK.
Dawid WalasSchool of Physiology, Pharmacology & Neuroscience, Medical Sciences, University of Bristol, Bristol, BS8 1TD, UK.
Danielle DeCiccoDaniel Baugh Institute for Functional Genomics and Computational Biology, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA.
Rajanikanth VadigepalliDaniel Baugh Institute for Functional Genomics and Computational Biology, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA.ORCID 0000-0002-8405-1037
James S SchwaberDaniel Baugh Institute for Functional Genomics and Computational Biology, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA.
Hidefumi WakiGraduate School of Health and Sports Science, Juntendo University, Chiba, Japan.
David MurphyHenry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Dorothy Hodgkin Building, University of Bristol, Whitson Street, Bristol, BS1 3NY, UK.
Julian F R PatonSchool of Physiology, Pharmacology & Neuroscience, Medical Sciences, University of Bristol, Bristol, BS8 1TD, UK. julian.f.r.paton@bristol.ac.uk.
University of Bristol · GBThomas Jefferson University · USGeorge Washington University · USJuntendo University · JP

Funding

Multiscale Model of Neural Control of BreathingR01NS069220 · NINDS · DREXEL UNIVERSITY · PI BEN-TAL, ALONA, DICK, THOMAS E · 2010 to 2014
$2.9M
Stress-induced hypertension and the role of the neuroimmune systemR00HL107675 · NHLBI · GEORGE WASHINGTON UNIVERSITY · PI MARVAR, PAUL J · 2014 to 2016
$746k
British Heart Foundation RG/11/28714British Heart Foundation RG/11/6/28714British Heart Foundation RG/12/6/29670NHLBI NIH HHS R00 HL107675NINDS NIH HHS R01 NS069220
6 · The paper itself

Abstract

key pointsEvidence indicates an association between hypertension and chronic systemic inflammation in both human hypertension and experimental animal models. Previous studies in the spontaneously hypertensive rat (SHR) support a role for leukotriene B ABSTRACT: Accumulating evidence indicates an association between hypertension and chronic systemic inflammation in both human hypertension and experimental animal models. Previous studies in the spontaneously hypertensive rat (SHR) support a role for leukotriene B

Indexed as

AnimalsArterial PressureBaroreflexBenzopyransCarboxylic AcidsHypertensionInflammationLeukotriene B4MacrophagesMaleRatsRats, Inbred SHRRats, Inbred WKYReceptors, Leukotriene B4BenzopyransCarboxylic AcidsCP 105696Leukotriene B4Ltb4r protein, ratReceptors, Leukotriene B4

Identifiers

PMID27230966
PMCPMC5063948
OpenAlexW2352136523

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.