SynthesisScientific reports2016
Diagnostic test accuracy of D-dimer for acute aortic syndrome: systematic review and meta-analysis of 22 studies with 5000 subjects.
Synthesis in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- Accuracy of using serum D-dimer for diagnosis of acute intestinal ischemia: A meta-analysis.Medicine · 2017Pooled it
- Article
- The Diagnostic Value of D-Dimer Testing in the Differential Diagnosis of Acute Abdomen in the Emergency Department.Journal of clinical medicine · 2026Review
- Article
- d-Dimer With the Aortic Dissection Detection Risk Score May Improve Patient Selection for Acute Aortic Syndrome Diagnostic Imaging.Emergency medicine Australasia : EMA · 2026Article
- Development and validation of identification models for aortic dissection and non-ST-segment elevation acute coronary syndrome in the emergency department.Scientific reports · 2025Article
- Radiomics-Based Machine Learning in the Diagnosis of Type-B Aortic Dissection on Computed Tomography Images.Pakistan journal of medical sciences · 2025Article
- Acute aortic dissection on CT: is D-dimer determination useful for a timely and correct diagnosis? A case report.International journal of emergency medicine · 2025Article
- Acute Aortic Syndromes from Diagnosis to Treatment-A Comprehensive Review.Journal of clinical medicine · 2024Review
- Aortic Dissection Detection Risk Score and D-Dimer for Acute Aortic Syndromes in the Chinese Population: Exploration of Optimal Thresholds and Integrated Diagnostic Value.Journal of cardiovascular translational research · 2023Article
- Clinical significance of D-dimer levels during acute period in ischemic stroke.Thrombosis journal · 2023Article
- The D-Dimer to Troponin Ratio Is a Novel Marker for the Differential Diagnosis of Thoracic Acute Aortic Syndrome from Non-ST Elevation Myocardial Infarction.Journal of clinical medicine · 2023Article
- Triglyceride to HDL-C ratio is associated with plasma D-dimer levels in different types of pancreatitis.Scientific reports · 2022Article
- A Retrospective Analysis of Serum D-Dimer Levels for the Exclusion of Acute Aortic Dissection.Open access emergency medicine : OAEM · 2022Article
- The influence of dipeptidyl peptidase-4 inhibitor on the progression of type B intramural hematoma.Frontiers in cardiovascular medicine · 2022Article
- Age-Adjusted D-Dimer in Ruling Out Acute Aortic Syndrome.Emergency medicine international · 2022Article
- The plasma D-dimer trends and their value in acute lower limb ischemia patients treated by catheter directed thrombolysis.Scientific reports · 2021Article
- Prognostic value of estimated glomerular filtration rate and presence of proteinuria in type B aortic intramural hematoma.Journal of thoracic disease · 2021Article
- Angiopoietin 2 as a Novel Potential Biomarker for Acute Aortic Dissection.Frontiers in cardiovascular medicine · 2021Article
- Aortic Dissection: A Review of the Pathophysiology, Management and Prospective Advances.Current cardiology reviews · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diagnostic test accuracy of D-dimer for acute aortic dissection (AAD) has not been evaluated by meta-analysis with the bivariate model methodology. Four databases were electrically searched. We included both case-control and cohort studies that could provide sufficient data concerning both sensitivity and specificity of D-dimer for AAD. Non-English language articles and conference abstract were allowed. Intramural hematoma and penetrating aortic ulcer were regarded as AAD. Based on 22 eligible articles consisting of 1140 AAD subjects and 3860 non-AAD subjects, the diagnostic odds ratio was 28.5 (95% CI 17.6-46.3, I(2) = 17.4%) and the area under curve was 0.946 (95% CI 0.903-0.994). Based on 833 AAD subjects and 1994 non-AAD subjects constituting 12 studies that used the cutoff value of 500 ng/ml, the sensitivity was 0.952 (95% CI 0.901-0.978), the specificity was 0.604 (95% CI 0.485-0.712), positive likelihood ratio was 2.4 (95% CI 1.8-3.3), and negative likelihood ratio was 0.079 (95% CI 0.036-0.172). Sensitivity analysis using data of three high-quality studies almost replicated these results. In conclusion, D-dimer has very good overall accuracy. D-dimer <500 ng/ml largely decreases the possibility of AAD. D-dimer >500 ng/ml moderately increases the possibility of AAD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.