Evidence map›Paper›PMID 27230960›Full record

ReviewNanomedicine (London, England)2016

Nanostructured injectable cell microcarriers for tissue regeneration.

Zhanpeng Zhang, Thomas W Eyster, Peter X Ma

Abstract readReview
In one paragraph

Review in Nanomedicine (London, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Zhanpeng ZhangDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109-1078, USA.
Thomas W EysterDepartment of Biologic & Materials Sciences, University of Michigan, Ann Arbor, MI 48109-1078, USA.
Peter X MaDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109-1078, USA.

Funding

Tissue Engineering and RegenerationT32DE007057 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID H. KOHN · 1985 to 2026
$17.3M
PTH and Calcium Synergy for Craniofacial RegenerationR01DE022327 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MCCAULEY, LAURIE K. · 2012 to 2022
$3.8M
Periodontal Engineering Using Biomimetic Nano ScaffoldsR01DE015384 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MA, PETER X · 2003 to 2011
$2.9M
Regenerating Blood Vessels Using iPS CellsR01HL114038 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MA, PETER X · 2013 to 2016
$2.1M
NHLBI NIH HHS R01 HL114038NIDCR NIH HHS R01 DE015384NIDCR NIH HHS R01 DE022327NIDCR NIH HHS T32 DE007057
6 · The paper itself

Abstract

Biodegradable polymer microspheres have emerged as cell carriers for the regeneration and repair of irregularly shaped tissue defects due to their injectability, controllable biodegradability and capacity for drug incorporation and release. Notably, recent advances in nanotechnology allowed the manipulation of the physical and chemical properties of the microspheres at the nanoscale, creating nanostructured microspheres mimicking the composition and/or structure of natural extracellular matrix. These nanostructured microspheres, including nanocomposite microspheres and nanofibrous microspheres, have been employed as cell carriers for tissue regeneration. They enhance cell attachment and proliferation, promote positive cell-carrier interactions and facilitate stem cell differentiation for target tissue regeneration. This review highlights the recent advances in nanostructured microspheres that are employed as injectable, biomimetic and cell-instructive cell carriers.

Indexed as

AnimalsBiocompatible MaterialsBiomimetic MaterialsCells, ImmobilizedDrug Delivery SystemsHumansInjectionsMicrospheresNanofibersNanomedicineNanostructuresNanotechnologyRegenerationRegenerative MedicineStem CellsTissue EngineeringBiocompatible Materialscell carriersinjectablenanocompositenanofiberporousstem celltissue regeneration

Identifiers

PMID27230960
PMCPMC5619097

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.