Evidence map›Paper›PMID 27230930›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2016

(2S)-2-(3-(1-Carboxy-5-(4-211At-Astatobenzamido)Pentyl)Ureido)-Pentanedioic Acid for PSMA-Targeted α-Particle Radiopharmaceutical Therapy.

Ana P Kiess, Il Minn, Ganesan Vaidyanathan, Robert F Hobbs, Anders Josefsson, Colette Shen, Mary Brummet, Ying Chen, Jaeyeon Choi, Eftychia Koumarianou and 6 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed
11.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 137 citations in OpenAlex.

  1. Trial
  2. TheEuropean journal of nuclear medicine and molecular imaging · 2017
    Trial
  3. Article
  4. Effective treatment of human prostate carcinoma xenografts with Single-Dose PSMA-targeted [European journal of nuclear medicine and molecular imaging · 2026
    Article
  5. Review
  6. Therapeutic evaluation of [European journal of nuclear medicine and molecular imaging · 2025
    Article
  7. Review
  8. Preclinical evaluation of [European journal of nuclear medicine and molecular imaging · 2025
    Article
  9. Review
  10. Novel astatine (European journal of nuclear medicine and molecular imaging · 2025
    Article
  11. Review
  12. Preclinical evaluation ofEuropean journal of nuclear medicine and molecular imaging · 2025
    Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. In vivo stableEJNMMI radiopharmacy and chemistry · 2024
    Article
  18. Review
  19. Preclinical Evaluation of Biodistribution and Toxicity of [International journal of molecular sciences · 2024
    Article
  20. Recent advances in the development ofAnalytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2024
    Review

22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 1 country.

Ana P KiessDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Il MinnRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Ganesan VaidyanathanDepartment of Radiology, Duke University Medical Center, Durham, North Carolina; and.
Robert F HobbsDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Anders JosefssonRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Colette ShenDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Mary BrummetRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Ying ChenRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Jaeyeon ChoiDepartment of Radiology, Duke University Medical Center, Durham, North Carolina; and.
Eftychia KoumarianouDepartment of Radiology, Duke University Medical Center, Durham, North Carolina; and.
Kwamena BaidooCenter for Cancer Research, National Cancer Institute, Bethesda, Maryland.
Martin W BrechbielCenter for Cancer Research, National Cancer Institute, Bethesda, Maryland.
Ronnie C MeaseRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland.
George SgourosDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Michael R ZalutskyDepartment of Radiology, Duke University Medical Center, Durham, North Carolina; and.
Martin G PomperDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland mpomper@jhmi.edu.
Johns Hopkins University · USDuke Medical Center · USDuke University Hospital · USJohns Hopkins Medicine · USNational Cancer Institute · US

Funding

Metal Chelate Conjugated Monoclonal Antibodies for Tumor Diagnosis and TherapyZIASC006353 · NCI · DIVISION OF CLINICAL SCIENCES - NCI · PI BRECHBIEL, MARTIN W · 2009 to 2017
$9.4M
PSMA-based Cancer Imaging AgentsR01CA134675 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI POMPER, MARTIN G · 2009 to 2025
$6.2M
Small Molecule PSMA-Targeted Alpha TherapyR01CA184228 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI POMPER, MARTIN G, ZALUTSKY, MICHAEL ROD · 2014 to 2023
$3.6M
Modeling Targeted Alpha Particle Therapy of CancerR01CA157542 · NCI · JOHNS HOPKINS UNIVERSITY · PI HOBBS, ROBERT FRANCOIS · 2012 to 2015
$1.3M
NCI NIH HHS R01 CA134675NCI NIH HHS R01 CA157542NCI NIH HHS R01 CA184228
6 · The paper itself

Abstract

Alpha-particle emitters have a high linear energy transfer and short range, offering the potential for treating micrometastases while sparing normal tissues. We developed a urea-based,

methodsPSMA-targeted (2S)-2-(3-(1-carboxy-5-(4-

results

conclusionPSMA-targeted

Indexed as

Alpha ParticlesAnimalsAntigens, SurfaceCell Line, TumorGlutamate Carboxypeptidase IIHumansKidneyMaximum Tolerated DoseMiceOrganometallic CompoundsRadiochemistryRadiopharmaceuticalsTissue DistributionUrea2-(3-(1-carboxy-5-(4-astatobenzamido)pentyl)ureido)pentanedioic acidAntigens, SurfaceFOLH1 protein, humanGlutamate Carboxypeptidase IIOrganometallic CompoundsRadiopharmaceuticalsUreaalpha emitterastatineoncology: GUprostate cancerprostate-specific membrane antigenradiation dosimetryradionuclide therapyradiopharmaceuticals

Identifiers

PMID27230930
PMCPMC5367442
OpenAlexW2403516958

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.