ArticleNeurochemical research2016
Alteration of Cytokines Levels in the Striatum of Rats: Possible Participation in Vacuous Chewing Movements Induced by Antipsycotics.
Article in Neurochemical research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- A single dose of haloperidol decanoate induces short-term hippocampal neuroinflammation: focus on the glial response.Pharmacological reports : PR · 2025Article
- Cannabigerol Mitigates Haloperidol-Induced Vacuous Chewing Movements in Mice.Neurotoxicity research · 2024Article
- Effects of Acute Haloperidol Treatment on Dopaminergic Markers, GADNeurochemical research · 2024Article
- Effects of association between resveratrol and ketamine on behavioral and biochemical analysis in mice.Journal of neural transmission (Vienna, Austria : 1996) · 2024Article
- Putative role of immune reactions in the mechanism of tardive dyskinesia.Brain, behavior, & immunity - health · 2023Review
- Reversal of haloperidol-induced orofacial dyskinesia and neuroinflammation by isoflavones.Molecular biology reports · 2022Article
- Genetic Factors Associated With Tardive Dyskinesia: From Pre-clinical Models to Clinical Studies.Frontiers in pharmacology · 2021Review
- Assessment of antipsychotic-induced cytotoxic effects on isolated CD1 mouse pancreatic beta cells.International journal of health sciencesArticle
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antipsychotic drugs have been used in the treatment of schizophrenia and their long-term use can cause movement disorders, such as tardive dyskinesia (TD) in humans mainly typical ones such as haloperidol. Neuroinflammation has been implicated to the use of antipsychotics besides its participation in TD remains unclear. Thus, the aim of this study was to investigate the relation of cytokines with vacuous chewing movements (VCMs) in rats comparing typical and atypical antipsychotics. Rats were treated with haloperidol or risperidone for 28 days. On day 29, rats were subjected to behavioral analysis (quantification of crossing and rearing numbers and VCMs) with subsequent measurement of cytokines levels in the striatum. Haloperidol, but not risperidone treatment significantly decreased the number of crossing and rearing and increased the VCMs when compared with control group. Both antipsychotics were able to increase the levels of pro-inflammatory cytokines (IL-1β, IL-6, TNF-α and IFN-γ) and decrease the anti-inflammatory cytokine (IL-10) in striatum of rats. However, IL-1β and IFN-γ levels were higher in animals treated with haloperidol than risperidone. Furthermore, positive correlations were observed between the cytokines (IL-1β and IFN-γ) and VCM numbers. Thus, the results suggest a role of inflammatory markers in the development of movement disorders, especially IL-1β and IFN-γ.
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