Trial reportStress (Amsterdam, Netherlands)2016
Acute stress impairs cognitive flexibility in men, not women.
Trial report in Stress (Amsterdam, Netherlands), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03353441 (Effects of Microencapsulated Sublingual Glycine), which is not on this map. Cited by 41 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Microencapsulated Sublingual Glycine (Bidicin) on Cognitive Performance in Healthy Men After an Acute Stressor - a Randomized, Partly Double-blind Placebo-controlled Clinical Trial
Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The effects of acute stress on core executive functions: A meta-analysis and comparison with cortisol.Neuroscience and biobehavioral reviews · 2016Pooled it
- Acute Stress Impacts Executive-Social Function: Evidence From Prefrontal Activation and fNIRS-Based Hyperscanning.Brain and behavior · 2026Trial
- The effect of acute stress on executive function in children: Moderation by parasympathetic nervous system activity.Journal of experimental child psychology · 2026Article
- Acute stress impairs decision-making at varying levels of decision complexity.Communications psychology · 2025Article
- The null effect of stress on cognitive flexibility in individuals with and without alcohol use disorder.Drug and alcohol dependence · 2025Article
- How to Improve Cognitive Flexibility: Evidence From Noninvasive Neuromodulation Techniques.CNS neuroscience & therapeutics · 2025Review
- Valence-Driven Cognitive Flexibility: Neurochemical and Circuit-Level Insights from Animal Models and Their Relevance to Schizophrenia.Biomolecules · 2025Review
- Homocysteine Mediates Cognitive Inflexibility Induced by Stress via Targeting PIN1.Brain sciences · 2025Article
- Stay social, stay young: a bioanthropological outlook on the processes linking sociality and ageing.GeroScience · 2025Review
- Resilience phenotypes derived from an active inference account of allostasis.Frontiers in behavioral neuroscience · 2025Article
- Effects of chronic stress on cognitive function - From neurobiology to intervention.Neurobiology of stress · 2024Review
- The Role of Mindfulness Therapy in the Treatment of Chronic Pain.Current pain and headache reports · 2024Review
- Neural and Behavioral Measures of Stress-induced Impairment in Error Awareness and Post-error Adjustment.Neuroscience bulletin · 2024Article
- Article
- Sadness-Based Approach-Avoidance Modification Training for Subjective Stress in Adults: Pilot Randomized Controlled Trial.JMIR formative research · 2023Article
- The Insidious Influence of Stress: An Integrated Model of Stress, Executive Control, and Psychopathology.Clinical psychological science : a journal of the Association for Psychological Science · 2023Article
- Cognitive flexibility assessment with a new Reversal learning task paradigm compared with the Wisconsin card sorting test exploring the moderating effect of gender and stress.Psychological research · 2023Article
- Effects of neuromodulation on cognitive and emotional responses to psychosocial stressors in healthy humans.Neurobiology of stress · 2023Review
- Alternative interventions in clinical mental health settings: A survey of mental health professionals' perceptions.Complementary therapies in clinical practice · 2022Article
- Inter-relationships between changes in stress, mindfulness, and dynamic functional connectivity in response to a social stressor.Scientific reports · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Psychosocial stress influences cognitive abilities, such as long-term memory retrieval. However, less is known about the effects of stress on cognitive flexibility, which is mediated by different neurobiological circuits and could thus be regulated by different neuroendocrine pathways. In this study, we randomly assigned healthy adults to an acute stress induction or control condition and subsequently assessed participants' cognitive flexibility using an open-source version of the Wisconsin Card Sort task. Drawing on work in rodents, we hypothesized that stress would have stronger impairing effects on cognitive flexibility in men than women. As predicted, we found that stress impaired cognitive flexibility in men but did not significantly affect women. Our results thus indicate that stress exerts sex-specific effects on cognitive flexibility in humans and add to the growing body of research highlighting the need to consider sex differences in effects of stress.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.