Evidence map›Paper›PMID 27230762›Full record

ArticleJournal of autism and developmental disorders2016

Brief Report: Reduced Restricted and Repetitive Behaviors after Pivotal Response Treatment.

Pamela E Ventola, Daniel Yang, Sebiha M Abdullahi, Courtney A Paisley, Megan L Braconnier, Denis G Sukhodolsky

Registry-linked trialAbstract read
In one paragraph

Article in Journal of autism and developmental disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03848481 (Cannabidivarin), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03848481 phase2terminatednot on this mapstarted 2020, after this paper: background citation

Cannabidivarin (CBDV) vs. Placebo in Children and Adults up to Age 30 With Prader-Willi Syndrome (PWS)

TypeinterventionalSponsorEric HollanderRan2020 to 2024Enrolled6ConditionsPrader-Willi SyndromeArmsCBDV Compound, Placebo
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Trial
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  5. Article
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  11. Psychometric analysis of the repetitive behavior scale-revised using confirmatory factor analysis in children with autism.Autism research : official journal of the International Society for Autism Research · 2019
    Article
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  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Pamela E VentolaYale Child Study Center, Yale University School of Medicine, 230 South Frontage Road, PO Box 207900, New Haven, CT, 06520-7900, USA. pamela.ventola@yale.edu.
Daniel YangYale Child Study Center, Yale University School of Medicine, 230 South Frontage Road, PO Box 207900, New Haven, CT, 06520-7900, USA.
Sebiha M AbdullahiYale Child Study Center, Yale University School of Medicine, 230 South Frontage Road, PO Box 207900, New Haven, CT, 06520-7900, USA.
Courtney A PaisleyYale Child Study Center, Yale University School of Medicine, 230 South Frontage Road, PO Box 207900, New Haven, CT, 06520-7900, USA.
Megan L BraconnierYale Child Study Center, Yale University School of Medicine, 230 South Frontage Road, PO Box 207900, New Haven, CT, 06520-7900, USA.
Denis G SukhodolskyYale Child Study Center, Yale University School of Medicine, 230 South Frontage Road, PO Box 207900, New Haven, CT, 06520-7900, USA.
Yale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Multimodal Developmental Neurogenetics of Females with ASDR01MH100028 · NIMH · YALE UNIVERSITY · PI Allison Elizabeth Jack, LAUREN KENWORTHY · 2012 to 2026
$37.8M
NCATS NIH HHS UL1 TR001863NIMH NIH HHS R01 MH100028
6 · The paper itself

Abstract

Children with ASD show high frequency of restricted and repetitive behaviors (RRBs); however, higher-order RRBs, such as restricted interests, have remained largely resistant to treatment. This study evaluated change in severity of RRBs following a 16-weeks open trial of Pivotal Response Treatment (PRT). Participants included 15 children with ASD ages 4-7 years. RRBs, as measured by the repetitive behavioral scales-revised (RBS-R) and aberrant behaviors checklist, decreased significantly after treatment. These reductions remained significant after controlling for change in social communication skills. PRT shows promise in reducing RRBs; although PRT explicitly addresses pivotal social communication skills, there is a secondary and less direct effect on RRBs.

Indexed as

Social SkillsAutism Spectrum DisorderBehavior TherapyChildChild Behavior DisordersChild, PreschoolCommunicationFemaleHumansMalePilot ProjectsTreatment OutcomeBehavior therapyPivotal Response Treatment (PRT)Repetitive Behavior Scale-Revised (RBS-R)Restricted and repetitive behaviors

Identifiers

PMID27230762
PMCPMC4939123
OpenAlexW2403797801

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.