ReviewTrends in genetics : TIG2016
Stepwise Progression of Embryonic Patterning.
Review in Trends in genetics : TIG, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Spatiotemporal analysis of genetic perturbations reveals a genetic cascade driving Tribolium gap gene initialization.Biology open · 2026Article
- Prediction and analysis of cis-regulatory elements in Dorsal and Ventral patterning genes of Tribolium castaneum and its comparison with Drosophila melanogaster.Molecular and cellular biochemistry · 2024Article
- Transcriptome profile in Drosophila Kc and S2 embryonic cell lines.G3 (Bethesda, Md.) · 2023Article
- Cell-specific occupancy dynamics between the pioneer-like factor Opa/ZIC and Ocelliless/OTX regulate early head development in embryos.Frontiers in cell and developmental biology · 2023Article
- Accessible chromatin reveals regulatory mechanisms underlying cell fate decisions during early embryogenesis.Scientific reports · 2021Article
- Independence of chromatin conformation and gene regulation during Drosophila dorsoventral patterning.Nature genetics · 2021Article
- Twist-dependent ratchet functioning downstream from Dorsal revealed using a light-inducible degron.Genes & development · 2020Article
- Distinct Roles of Broadly Expressed Repressors Support Dynamic Enhancer Action and Change in Time.Cell reports · 2019Article
- Article
- A gene expression atlas of embryonic neurogenesis inDevelopment (Cambridge, England) · 2019Article
- A Developmental Program Truncates Long Transcripts to Temporally Regulate Cell Signaling.Developmental cell · 2018Article
- Temporal control of gene expression by the pioneer factor Zelda through transient interactions in hubs.Nature communications · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
It is long established that the graded distribution of Dorsal transcription factor influences spatial domains of gene expression along the dorsoventral (DV) axis of Drosophila melanogaster embryos. However, the more recent realization that Dorsal levels also change with time raises the question of whether these dynamics are instructive. An overview of DV axis patterning is provided, focusing on new insights identified through quantitative analysis of temporal changes in Dorsal target gene expression from one nuclear cycle to the next ('steps'). Possible roles for the stepwise progression of this patterning program are discussed including (i) tight temporal regulation of signaling pathway activation, (ii) control of gene expression cohorts, and (iii) ensuring the irreversibility of the patterning and cell fate specification process.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.