Evidence map›Paper›PMID 27230674›Full record

ReviewJournal of cardiovascular translational research2016

Why QRS Duration Should Be Replaced by Better Measures of Electrical Activation to Improve Patient Selection for Cardiac Resynchronization Therapy.

Elien B Engels, Masih Mafi-Rad, Antonius M W van Stipdonk, Kevin Vernooy, Frits W Prinzen

Abstract readReview
In one paragraph

Review in Journal of cardiovascular translational research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Journal of cardiovascular development and disease · 2023
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Determinants of LV dP/dtOpen heart · 2021
    Observational
  11. Article
  12. Review
  13. Article
  14. Novel approach to discriminate left bundle branch block from nonspecific intraventricular conduction delay using pacing-induced functional left bundle branch block.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2018
    Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Elien B EngelsDepartment of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands.
Masih Mafi-RadDepartment of Cardiology, Maastricht University Medical Center, Maastricht, The Netherlands.
Antonius M W van StipdonkDepartment of Cardiology, Maastricht University Medical Center, Maastricht, The Netherlands.
Kevin VernooyDepartment of Cardiology, Maastricht University Medical Center, Maastricht, The Netherlands.
Frits W PrinzenDepartment of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands. frits.prinzen@maastrichtuniversity.nl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiac resynchronization therapy (CRT) is a well-known treatment modality for patients with a reduced left ventricular ejection fraction accompanied by a ventricular conduction delay. However, a large proportion of patients does not benefit from this therapy. Better patient selection may importantly reduce the number of non-responders. Here, we review the strengths and weaknesses of the electrocardiogram (ECG) markers currently being used in guidelines for patient selection, e.g., QRS duration and morphology. We shed light on the current knowledge on the underlying electrical substrate and the mechanism of action of CRT. Finally, we discuss potentially better ECG-based biomarkers for CRT candidate selection, of which the vectorcardiogram may have high potential.

Indexed as

Action PotentialsCardiac Resynchronization TherapyElectrocardiographyPatient SelectionElectrophysiologic Techniques, CardiacHeart Conduction SystemHeart FailureHeart RateHumansPredictive Value of TestsStroke VolumeTime FactorsVentricular Dysfunction, LeftVentricular Function, LeftCardiac mappingCardiac resynchronization therapyElectrocardiographyLeft bundle-branch blockVectorcardiography

Identifiers

PMID27230674
PMCPMC4990608

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.