Evidence map›Paper›PMID 27230669›Full record

ArticleLa Radiologia medica2016

Resected pN1 non-small cell lung cancer: recurrence patterns and nodal risk factors may suggest selection criteria for post-operative radiotherapy.

Paolo Borghetti, Fernando Barbera, Marco Lorenzo Bonù, Francesca Trevisan, Stefano Ciccarelli, Paola Vitali, Marta Maddalo, Luca Triggiani, Nadia Pasinetti, Sara Pedretti and 6 more

Abstract read
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In one paragraph

Article in La Radiologia medica, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Development and Validation of a Predictive Nomogram for Early Postoperative Recurrence in Non-Small Cell Lung Cancer.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Paolo BorghettiDepartment of Radiation Oncology, Spedali Civili of Brescia, P.le Spedali Civili 1, 25124, Brescia, Italy. paolobor82@yahoo.it7.
Fernando BarberaDepartment of Radiation Oncology, Spedali Civili of Brescia, P.le Spedali Civili 1, 25124, Brescia, Italy.
Marco Lorenzo BonùDepartment of Radiation Oncology, Brescia University, Brescia, Italy.
Francesca TrevisanDepartment of Radiation Oncology, Brescia University, Brescia, Italy.
Stefano CiccarelliDepartment of Radiation Oncology, Brescia University, Brescia, Italy.
Paola VitaliDepartment of Radiation Oncology, Spedali Civili of Brescia, P.le Spedali Civili 1, 25124, Brescia, Italy.
Marta MaddaloDepartment of Radiation Oncology, Spedali Civili of Brescia, P.le Spedali Civili 1, 25124, Brescia, Italy.
Luca TriggianiDepartment of Radiation Oncology, Brescia University, Brescia, Italy.
Nadia PasinettiDepartment of Radiation Oncology, Spedali Civili of Brescia, P.le Spedali Civili 1, 25124, Brescia, Italy.
Sara PedrettiDepartment of Radiation Oncology, Brescia University, Brescia, Italy.
Bartolomea BonettiDepartment of Radiation Oncology, Spedali Civili of Brescia, P.le Spedali Civili 1, 25124, Brescia, Italy.
Gianluca PariscentiDepartment of Thoracic Surgery, Spedali Civili of Brescia, Brescia, Italy.
Andrea TironiDepartment of Pathology, Spedali Civili of Brescia, Brescia, Italy.
Alberto CaprioliDepartment of Pneumology, Spedali Civili of Brescia, Brescia, Italy.
Michela BuglioneDepartment of Radiation Oncology, Brescia University, Brescia, Italy.
Stefano Maria MagriniDepartment of Radiation Oncology, Brescia University, Brescia, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo describe the pattern of recurrence in resected pN1 non-small cell lung cancer (NSCLC) and to identify factors predicting an increased risk of locoregional recurrence (LR) or distant metastasis (DM) to define a selected population who may benefit from postoperative radiotherapy (PORT).

methods285 patients with resected pN1 NSCLC were identified. Patients with positive surgical margins, undergoing neoadjuvant treatment or PORT, were excluded. LR was defined as first event of recurrence at the surgical bed, ipsilateral hilum or mediastinum, and other sites were considered as DM. Kaplan-Meier actuarial estimates of overall survival (OS), progression-free survival (PFS), freedom from LR (FFLR) and freedom from DM (FFDM) in different subgroups were compared with the log-rank test. Multivariate analysis was calculated.

results202 patients met the inclusion criteria, 24 % received adjuvant chemotherapy. The median follow-up was 39 months. The total number of recurrences was 118 (64.4 %): 44 (24 %) and 74 (40.4 %) for LR and DM, respectively. Five-year OS and PFS rates were 39.2 and 33.3 %, respectively. Extra capsular extension (ECE) (RR 2.10, p = 0.01) and lymph nodal ratio (LNR) >0:15 (RR 1.68, p = 0.015) were associated with a worse PFS. ECE and LNR >0.15 were significantly related to a worst FFLR (RR 3.04 and 4.42, respectively), and adenocarcinoma to an unfavorable FFDM (RR 1.97, p = 0.013).

conclusionsNodal factors as high LNR and ECE can predict an increased risk of worse FFLR and PFS. Prospective data on selected patients, treated with modern radiotherapy techniques, need to be collected to re-evaluate the role of radiotherapy.

Indexed as

AdultAgedAged, 80 and overCarcinoma, Non-Small-Cell LungChemotherapy, AdjuvantCombined Modality TherapyFemaleHumansLung NeoplasmsLymphatic MetastasisMaleMiddle AgedNeoplasm GradingNeoplasm Recurrence, LocalRisk FactorsTreatment OutcomeDistant metastasisExtra capsular extensionLocoregional recurrenceLymph node ratioNon-small cell lung cancerPathologic N1

Identifiers

PMID27230669

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.