Evidence map›Paper›PMID 27230411›Full record

ArticleScientific reports2016

Continuity of Monolayer-Bilayer Junctions for Localization of Lipid Raft Microdomains in Model Membranes.

Yong-Sang Ryu, Nathan J Wittenberg, Jeng-Hun Suh, Sang-Wook Lee, Youngjoo Sohn, Sang-Hyun Oh, Atul N Parikh, Sin-Doo Lee

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 16 citations in OpenAlex.

  1. Mimicking Cellular Membranes With Micropatterned Lipid Bilayers.Chemphyschem : a European journal of chemical physics and physical chemistry · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Yong-Sang RyuSchool of Electrical Engineering #032, Seoul National University, Kwanak P.O. Box 34, Seoul 151-600 Korea.
Nathan J WittenbergDepartment of Electrical and Computer Engineering, University of Minnesota, Minneapolis, Minnesota 55455, USA.
Jeng-Hun SuhSchool of Electrical Engineering #032, Seoul National University, Kwanak P.O. Box 34, Seoul 151-600 Korea.
Sang-Wook LeeSchool of Electrical Engineering #032, Seoul National University, Kwanak P.O. Box 34, Seoul 151-600 Korea.
Youngjoo SohnDepartment of Anatomy, College of Korean Medicine, Institute of Oriental Medicine, Kyung Hee University, Seoul 130-701, Korea.
Sang-Hyun OhDepartment of Electrical and Computer Engineering, University of Minnesota, Minneapolis, Minnesota 55455, USA.
Atul N ParikhDepartments of Biomedical Engineering and Chemical Engineering &Materials Science, University of California, Davis, California 95616, USA.
Sin-Doo LeeSchool of Electrical Engineering #032, Seoul National University, Kwanak P.O. Box 34, Seoul 151-600 Korea.
Seoul National University · KRUniversity of Minnesota · USKyung Hee University · KRUniversity of California, Davis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We show that the selective localization of cholesterol-rich domains and associated ganglioside receptors prefer to occur in the monolayer across continuous monolayer-bilayer junctions (MBJs) in supported lipid membranes. For the MBJs, glass substrates were patterned with poly(dimethylsiloxane) (PDMS) oligomers by thermally-assisted contact printing, leaving behind 3 nm-thick PDMS patterns. The hydrophobicity of the transferred PDMS patterns was precisely tuned by the stamping temperature. Lipid monolayers were formed on the PDMS patterned surface while lipid bilayers were on the bare glass surface. Due to the continuity of the lipid membranes over the MBJs, essentially free diffusion of lipids was allowed between the monolayer on the PDMS surface and the upper leaflet of the bilayer on the glass substrate. The preferential localization of sphingomyelin, ganglioside GM1 and cholesterol in the monolayer region enabled to develop raft microdomains through coarsening of nanorafts. Our methodology provides a simple and effective scheme of non-disruptive manipulation of the chemical landscape associated with lipid phase separations, which leads to more sophisticated applications in biosensors and as cell culture substrates.

Indexed as

Cholera ToxinCholesterolG(M1) GangliosideHydrophobic and Hydrophilic InteractionsLipid BilayersMembrane MicrodomainsModels, BiologicalProtein BindingReceptors, Cell SurfaceSphingomyelinsCholera ToxinCholesterolganglioside receptorG(M1) GangliosideLipid BilayersReceptors, Cell SurfaceSphingomyelins

Identifiers

PMID27230411
PMCPMC4882513
OpenAlexW2396462964

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.