ArticleCerebral cortex (New York, N.Y. : 1991)2016
Cortical Dependence of Whisker Responses in Posterior Medial Thalamus In Vivo.
Article in Cerebral cortex (New York, N.Y. : 1991), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 47 citations in OpenAlex.
- Single-cell reconstruction of whole-brain efferent projections from mouse ventral posteromedial thalamus.Brain informatics · 2026Article
- Modulation and Gating of Transthalamic and Subcortical Pathways through Somatosensory Thalamus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Layer 5 myelination gates corticothalamic coincidence detection.Nature communications · 2025Article
- Thalamus enables active dendritic coupling of inputs arriving at different cortical layers.Nature communications · 2025Article
- Active and passive touch are differentially represented in the mouse somatosensory thalamus.PLoS biology · 2025Article
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- Highly branched and complementary distributions of layer 5 and layer 6 auditory corticofugal axons in mouse.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Posteromedial thalamic nucleus activity significantly contributes to perceptual discrimination.PLoS biology · 2022Article
- Dissection of brain-wide resting-state and functional somatosensory circuits by fMRI with optogenetic silencing.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Distinct "driving" versus "modulatory" influences of different visual corticothalamic pathways.Current biology : CB · 2021Article
- High-frequency burst spiking in layer 5 thick-tufted pyramids of rat primary somatosensory cortex encodes exploratory touch.Communications biology · 2021Article
- Early fMRI responses to somatosensory and optogenetic stimulation reflect neural information flow.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Higher-Order Thalamic Encoding of Somatosensory Patterns and Bilateral Events.Frontiers in neural circuits · 2021Article
- Corticothalamic Pathways From Layer 5: Emerging Roles in Computation and Pathology.Frontiers in neural circuits · 2021Review
- Mapping the Brain-Wide Network Effects by Optogenetic Activation of the Corpus Callosum.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Anatomically and functionally distinct thalamocortical inputs to primary and secondary mouse whisker somatosensory cortices.Nature communications · 2020Article
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- Trans-thalamic Pathways: Strong Candidates for Supporting Communication between Functionally Distinct Cortical Areas.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Reduced sensory-evoked structural plasticity in the aging barrel cortex.Neurobiology of aging · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cortical layer 5B (L5B) thick-tufted pyramidal neurons have reliable responses to whisker stimulation in anesthetized rodents. These cells drive a corticothalamic pathway that evokes spikes in thalamic posterior medial nucleus (POm). While a subset of POm has been shown to integrate both cortical L5B and paralemniscal signals, the majority of POm neurons are suggested to receive driving input from L5B only. Here, we test this possibility by investigating the origin of whisker-evoked responses in POm and specifically the contribution of the L5B-POm pathway. We compare L5B spiking with POm spiking and subthreshold responses to whisker deflections in urethane anesthetized mice. We find that a subset of recorded POm neurons shows early (<50 ms) spike responses and early large EPSPs. In these neurons, the early large EPSPs matched L5B input criteria, were blocked by cortical inhibition, and also interacted with spontaneous Up state coupled large EPSPs. This result supports the view of POm subdivisions, one of which receives whisker signals predominantly via L5B neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.