ArticleCerebral cortex (New York, N.Y. : 1991)2016
Longitudinal Evidence for Smaller Hippocampus Volume as a Vulnerability Factor for Perceived Stress.
Article in Cerebral cortex (New York, N.Y. : 1991), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of neuroimaging studies of adults aged 35 and older with clinical, symptomatic and genetic risk for attention-deficit/hyperactivity disorder.Dialogues in clinical neuroscience · 2026Pooled it
- Trial
- Cumulative trauma, neural circuits, and burnout: an integrative model of healthcare worker post-traumatic stress syndromes.European journal of psychotraumatology · 2026Review
- Alterations in gray matter microstructure and functional connectivity after acute stress.European journal of psychotraumatology · 2026Article
- Exploring the role of apolipoprotein ε4 in progressive myoclonic epilepsy type 1.Epileptic disorders : international epilepsy journal with videotape · 2026Article
- Social stress, cortisol awakening response and sex: association with hippocampus and amygdala volume.Biology of sex differences · 2025Article
- The association between recent stressful life events and brain structure: a UK Biobank longitudinal MRI study.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Plasticity of human resilience mechanisms.Science advances · 2025Article
- Neuroimaging of posttraumatic stress disorder in adults and youth: progress over the last decade on three leading questions of the field.Molecular psychiatry · 2024Review
- Revised Temperament and Character Inventory factors predict neuropsychiatric symptoms and aging-related cognitive decline across 25 years.Frontiers in aging neuroscience · 2024Article
- Evaluation of brain structure and metabolism in currently depressed adults with a history of childhood trauma.Translational psychiatry · 2022Article
- Perceived stress associations with hippocampal-dependent behavior and hippocampal subfield volume.Neurobiology of stress · 2022Article
- The Use of Neuroimaging for Predicting Sumatriptan Treatment Response in Patients With Migraine.Frontiers in neurology · 2022Article
- Peroxisome proliferator-activated receptor gamma: a novel therapeutic target for cognitive impairment and mood disorders that functions via the regulation of adult neurogenesis.Archives of pharmacal research · 2021Review
- Hippocampal seed connectome-based modeling predicts the feeling of stress.Nature communications · 2020Article
- Hippocampal Shape Maturation in Childhood and Adolescence.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- BDNF and COMT, but not APOE, alleles are associated with psychiatric symptoms in refractory epilepsy.Epilepsy & behavior : E&B · 2019Article
- Increased stressor-evoked cardiovascular reactivity is associated with reduced amygdala and hippocampus volume.Psychophysiology · 2019Article
- Perceived stress is associated with smaller hippocampal volume in adolescence.Psychophysiology · 2018Article
- Neuroscience Informed Prolonged Exposure Practice: Increasing Efficiency and Efficacy Through Mechanisms.Frontiers in behavioral neuroscience · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hippocampal volume has been found to be smaller in individuals with stress-related disorders, but it remains unclear whether smaller volume is a consequence of stress or rather a vulnerability factor. Here, we examined this issue by relating stress levels to hippocampal volumes in healthy participants examined every 5 years in a longitudinal population-based study. Based on scores of 25- to 60-year-old participants on the perceived stress questionnaire, we defined moderately to high (n = 35) and low (n = 76) stress groups. The groups were re-examined after 5 years (at the 6th study wave). Historical data on subjective stress were available up to 10 years prior to Wave 5. At the first MRI session, the moderately to high stress group had a significantly smaller hippocampal volume, as measured by FreeSurfer (version 5.3), compared with the low-stress group. At follow-up, group differences in stress levels and hippocampal volume remained unchanged. In retrospective analyses of subjective stress, the observed group difference in stress was found to be stable. The long-term stability of group differences in perceived stress and hippocampal volume suggests that a small hippocampal volume may be a vulnerability factor for stress-related disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.