Evidence map›Paper›PMID 27229879›Full record

ArticleMedical molecular morphology2017

Correlation of intratumoral lymphatic microvessel density, vascular endothelial growth factor C and cell proliferation in salivary gland tumors.

Márcia Gimenes Americo, Yonara Maria Freire Soares Marques, Milagros Del Valle El Abras Ankha, Renata Falchete do Prado, Yasmin Rodarte Carvalho

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In one paragraph

Article in Medical molecular morphology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Márcia Gimenes AmericoDepartment of Bioscience and Oral Diagnosis, Dental School-Institute of Science and Technology (ICT), Univ. Estadual Paulista (UNESP), Av. Engenheiro Francisco José Longo, 777, São José dos Campos, São Paulo, 12245-000, Brazil. gimenesgimenes@hotmail.com.
Yonara Maria Freire Soares MarquesDepartment of Bioscience and Oral Diagnosis, Dental School-Institute of Science and Technology (ICT), Univ. Estadual Paulista (UNESP), Av. Engenheiro Francisco José Longo, 777, São José dos Campos, São Paulo, 12245-000, Brazil.
Milagros Del Valle El Abras AnkhaDepartment of Bioscience and Oral Diagnosis, Dental School-Institute of Science and Technology (ICT), Univ. Estadual Paulista (UNESP), Av. Engenheiro Francisco José Longo, 777, São José dos Campos, São Paulo, 12245-000, Brazil.
Renata Falchete do PradoDepartment of Bioscience and Oral Diagnosis, Dental School-Institute of Science and Technology (ICT), Univ. Estadual Paulista (UNESP), Av. Engenheiro Francisco José Longo, 777, São José dos Campos, São Paulo, 12245-000, Brazil.
Yasmin Rodarte CarvalhoDepartment of Bioscience and Oral Diagnosis, Dental School-Institute of Science and Technology (ICT), Univ. Estadual Paulista (UNESP), Av. Engenheiro Francisco José Longo, 777, São José dos Campos, São Paulo, 12245-000, Brazil.
Universidade Estadual Paulista (Unesp) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lymphatic dissemination is one of the most important pathways for metastasis in many solid tumors, including head and neck carcinomas. The lymphatic growth of cancer has been used as a significant independent adverse prognostic factor and provides information about tumor progression. Salivary gland tumors present different prognoses and have the ability to develop metastases; however, this information regarding the lymphatic spread is scarce. This paper quantifies the lymphatic microvessel density (LMD) in benign and malignant salivary gland tumors and analyzes the relationship between LMD and tumor expression of vascular endothelial growth factors C (VEGF-C) and the proliferative index. The results show that there is no correlation between LMD, VEGF-C and the proliferative index in the majority of salivary gland tumors analyzed, apart from polymorphous low-grade carcinoma which exhibits statistical correlation between LMD and the proliferative index (p < 0.05). This correlation probably does not indicate a poor prognosis for this PLGA, since this is a low metastasizing carcinoma of the salivary glands. Different from other solid tumors, such as breast or prostatic carcinomas, there is no correlation between VEGF-C and LMD in salivary gland tumors, and so these traits are not able to estimate the metastatic risk or the prognosis of these tumors.

Indexed as

Antibodies, Monoclonal, Murine-DerivedBiomarkers, TumorCell ProliferationHumansImmunohistochemistryKi-67 AntigenLymphatic VesselsMicrovesselsSalivary Gland NeoplasmsVascular Endothelial Growth Factor CAntibodies, Monoclonal, Murine-DerivedBiomarkers, TumorKi-67 Antigenmonoclonal antibody D2-40Vascular Endothelial Growth Factor CLymphatic microvessel densityPrognosesProliferative indexSalivary gland tumorsVEGF-C

Identifiers

PMID27229879
OpenAlexW2395423872

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.