ArticleBiomechanics and modeling in mechanobiology2017
A mathematical model for the simulation of the formation and the subsequent regression of hypertrophic scar tissue after dermal wounding.
Article in Biomechanics and modeling in mechanobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- In Vivo Models for Hypertrophic Scars-A Systematic Review.Medicina (Kaunas, Lithuania) · 2022Pooled it
- Computational Modeling of Patient-Specific Healing and Deformation Outcomes Following Breast-Conserving Surgery Based on MRI Data.Annals of biomedical engineering · 2026Article
- A Mathematical Model of Wound Healing Incorporating Strain-Induced MSC Differentiation.Annals of biomedical engineering · 2026Article
- Biomorphoelasticity alone: limitations in modeling post-burn contraction and hypertrophy without finite strains.Biomechanics and modeling in mechanobiology · 2025Article
- Computational mechanobiology model evaluating healing of postoperative cavities following breast-conserving surgery.Computers in biology and medicine · 2023Article
- Computational Mechanobiology Model Evaluating Healing of Postoperative Cavities Following Breast-Conserving Surgery.bioRxiv : the preprint server for biology · 2023Article
- Stability of a two-dimensional biomorphoelastic model for post-burn contraction.Journal of mathematical biology · 2023Article
- Sensitivity of a two-dimensional biomorphoelastic model for post-burn contraction.Biomechanics and modeling in mechanobiology · 2023Article
- The Future of Burn Care From a Complexity Science Perspective.Journal of burn care & research : official publication of the American Burn Association · 2022Article
- Sensitivity and feasibility of a one-dimensional morphoelastic model for post-burn contraction.Biomechanics and modeling in mechanobiology · 2021Article
- Mechanobiological wound model for improved design and evaluation of collagen dermal replacement scaffolds.Acta biomaterialia · 2021Article
- Stability of a one-dimensional morphoelastic model for post-burn contraction.Journal of mathematical biology · 2021Article
- Immunological mechanisms of scarring and their psychological impact on patients.American journal of clinical and experimental immunology · 2021Review
- Research progress of scar repair and its influence on physical and mental health.International journal of burns and trauma · 2021Review
- Can Mathematics and Computational Modeling Help Treat Deep Tissue Injuries?Advances in wound care · 2019Article
- Technologies to monitor the health of loaded skin tissues.Biomedical engineering online · 2018Review
- Biomedical implications from a morphoelastic continuum model for the simulation of contracture formation in skin grafts that cover excised burns.Biomechanics and modeling in mechanobiology · 2017Article
- A mathematical model for the simulation of the contraction of burns.Journal of mathematical biology · 2017Article
- A biomechanical mathematical model for the collagen bundle distribution-dependent contraction and subsequent retraction of healing dermal wounds.Biomechanics and modeling in mechanobiology · 2017Article
- Prediction of Scar Size in Rats Six Months after Burns Based on Early Post-injury Polarization-Sensitive Optical Frequency Domain Imaging.Frontiers in physiology · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A continuum hypothesis-based model is presented for the simulation of the formation and the subsequent regression of hypertrophic scar tissue after dermal wounding. Solely the dermal layer of the skin is modeled explicitly and it is modeled as a heterogeneous, isotropic and compressible neo-Hookean solid. With respect to the constituents of the dermal layer, the following components are selected as primary model components: fibroblasts, myofibroblasts, a generic signaling molecule and collagen molecules. A good match with respect to the evolution of the thickness of the dermal layer of scars between the outcomes of simulations and clinical measurements on hypertrophic scars at different time points after injury in human subjects is demonstrated. Interestingly, the comparison between the outcomes of the simulations and the clinical measurements demonstrates that a relatively high apoptosis rate of myofibroblasts results in scar tissue that behaves more like normal scar tissue with respect to the evolution of the thickness of the tissue over time, while a relatively low apoptosis rate results in scar tissue that behaves like hypertrophic scar tissue with respect to the evolution of the thickness of the tissue over time. Our ultimate goal is to construct models with which the properties of newly generated tissues that form during wound healing can be predicted with a high degree of certainty. The development of the presented model is considered by us as a step toward their construction.
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