Evidence map›Paper›PMID 27229641›Full record

ReviewClinics in chest medicine2016

Sepsis Resuscitation: Fluid Choice and Dose.

Matthew W Semler, Todd W Rice

Open access · greenAbstract readReview
In one paragraph

Review in Clinics in chest medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Review
  4. Review
  5. Biomarkers to guide sepsis management.Annals of intensive care · 2025
    Review
  6. Review
  7. Sepsis Management in the Cardiac Intensive Care Unit.Journal of cardiovascular development and disease · 2023
    Review
  8. Article
  9. Review
  10. Fluid Stewardship of Maintenance Intravenous Fluids.Journal of pharmacy practice · 2022
    Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Septic shock in the ER: diagnostic and management challenges.Open access emergency medicine : OAEM · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Matthew W SemlerDivision of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Medical Center North, T-1218, Nashville, TN 37232-2650, USA. Electronic address: matthew.semler@vanderbilt.edu.
Todd W RiceDivision of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Medical Center North, T-1218, Nashville, TN 37232-2650, USA.
Vanderbilt University Medical Center · US

Funding

Clinical and Translational Training Program in Pulmonary MedicineT32HL087738 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Lorraine B Ware · 2007 to 2026
$7.0M
NHLBI NIH HHS T32 HL087738
6 · The paper itself

Abstract

Sepsis is a common and life-threatening inflammatory response to severe infection treated with antibiotics and fluid resuscitation. Despite the central role of intravenous fluid in sepsis management, fundamental questions regarding which fluid and in what amount remain unanswered. Recent advances in understanding the physiologic response to fluid administration, and large clinical studies examining resuscitation strategies, fluid balance after resuscitation, colloid versus crystalloid solutions, and high- versus low-chloride crystalloids, inform the current approach to sepsis fluid management and suggest areas for future research.

Indexed as

Crystalloid SolutionsFluid TherapyHumansIsotonic SolutionsResuscitationSepsisCrystalloid SolutionsIsotonic SolutionsAlbuminColloidsCrystalloidsEarly goal-directed therapyFluid resuscitationSepsis

Identifiers

PMID27229641
PMCPMC4884304
OpenAlexW2332155798

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.