ArticleVirchows Archiv : an international journal of pathology2016
Epithelioid angiosarcoma of the thyroid gland without distant metastases at diagnosis: report of six cases with a long follow-up.
Article in Virchows Archiv : an international journal of pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 27 citations in OpenAlex.
- Thyroid angiosarcoma: a rare malignancy - case report and systematic review of the literature.Thyroid research · 2025Review
- A Case Report of Surgical and Postoperative Treatment for Thyroid Angiosarcoma with Pulmonary Metastasis.Surgical case reports · 2025Article
- Primary Mesenchymal Tumors of the Thyroid Gland: A Modern Retrospective Cohort Including the First Case of TFE3-Translocated Malignant Perivascular Epithelioid Cell Tumor (PEComa).Head and neck pathology · 2022Article
- Morphology and one immunohistochemical marker are enough for diagnosis of primary thyroid angiosarcoma.Archive of clinical cases · 2021Article
- Thyroid angiosarcoma (TAS) - A rare diagnosis not to be missed.Clinical case reports · 2021Article
- Neoadjuvant Systemic Treatment of Primary Angiosarcoma.Cancers · 2020Review
- Primary Angiosarcoma of the Thyroid in an Asian Woman: A Case Report with Review of the Literature.Case reports in pathology · 2020Article
- Primary angiosarcoma of thyroid.BMJ case reports · 2019Article
- Angiosarcoma and anaplastic carcinoma of the thyroid are two distinct entities: a morphologic, immunohistochemical, and genetic study.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2019Article
- Immunohistochemical Biomarkers of Mesenchymal Neoplasms in Endocrine Organs: Diagnostic Pitfalls and Recent Discoveries.Endocrine pathology · 2018Review
- Primary Epithelioid Angiosarcoma of the Thyroid in a Patient Occupationally Exposed to Radiations.Frontiers in endocrinology · 2018Article
- Right femoral pathological fracture caused by primary bone epithelioid angiosarcoma: Case report.Medicine · 2017Article
- Thyroid Angiosarcoma-Rare Case or Hard to Find.Current health sciences journalArticle
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Authors and funding
7 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
We present six cases of epithelioid angiosarcomas (EAS) of the thyroid gland without distant metastases at diagnosis and with a long follow-up. We retrieved the six consecutive cases of thyroid EAS between 2005 and 2011. Gender was equally represented; median age was 60 years (range 53-68). One case was post-irradiation and another post-exposure to vinyl chloride. Median diameter was 6 cm (range 5-13). Regional nodal metastases were present at onset in two cases. All the cases expressed CD31 in a membranous pattern. CD34 was always negative. All the patients underwent complete surgical resection. Neoadjuvant chemotherapy was applied in one case and adjuvant chemotherapy in four cases with adjuvant radiation therapy in one case. Follow-up until June 2015 was available in five cases. Median follow-up was 59 months (range 9-82). Three patients relapsed. Two patients (the post-irradiation and post vinyl chloride exposure cases) died of disease after 36 and 9 months, after a local relapse soon followed by distant metastases. Three patients are alive and well after 59, 70, and 82 months, including a patient with a relapse treated with neoadjuvant chemotherapy and surgery. In conclusion, thyroid EAS without distant metastases at diagnosis are very rare tumors. They all expressed CD31, while CD34 was always negative. Distant metastases developed together with local relapse, rapidly followed by death. Inadequate surgery contributed to poor outcome. Cases with previous exposure to irradiation and vinyl chloride showed a particularly poor behavior.
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