SynthesisPediatric radiology2016
Magnetic resonance imaging in pediatric appendicitis: a systematic review.
Synthesis in Pediatric radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Rapid MRI Abdomen for Assessment of Clinically Suspected Acute Appendicitis in the General Adult Population: a Systematic Review.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2023Pooled it
- Magnetic resonance imaging (MRI) for diagnosis of acute appendicitis.The Cochrane database of systematic reviews · 2021Pooled it
- Deep learning reconstruction improves appendix visualization on pediatric magnetic resonance imaging (MRI): a single-center experience.Pediatric radiology · 2026Article
- Diagnosis of acute appendicitis at a pediatric emergency department within a general hospital.Emergency radiology · 2026Article
- Rapid abdominal MRI for appendicitis for evaluation of ovarian torsion in children.Emergency radiology · 2025Article
- Rapid abdominopelvic MR imaging in the emergency department: establishing a program and addressing the challenges.Pediatric radiology · 2025Review
- MRI Adoption in Pediatric Appendicitis: Trends and Outcomes.Hospital pediatrics · 2025Article
- Diagnostic Performance of Serum Leucine-Rich Alpha-2-Glycoprotein 1 in Pediatric Acute Appendicitis: A Prospective Validation Study.Biomedicines · 2024Article
- The Society for Pediatric Radiology Magnetic Resonance Imaging and Emergency and Trauma Imaging Committees' consensus protocol recommendation for rapid MRI for evaluating suspected appendicitis in children.Pediatric radiology · 2024Review
- Implementation of ultrasound and fast magnetic resonance imaging pathway reduces computed tomography utilization in children with suspected appendicitis.Pediatric surgery international · 2023Article
- A Review of Radiological Investigations in Cases of Acute Appendicitis in a Tertiary Care Hospital.Cureus · 2023Article
- Comparison of MRI appendix biometrics in children with and without acute appendicitis.European radiology · 2022Article
- Abdominal fellowship-trained versus generalist radiologist accuracy when interpreting MR and CT for the diagnosis of appendicitis.European radiology · 2022Observational
- Abdominal Pain in the Emergency Department: How to Select the Correct Imaging for Diagnosis.Open access emergency medicine : OAEM · 2022Review
- Acute appendicitis-advances and controversies.World journal of gastrointestinal surgery · 2021Review
- Brief Report: Association of Complicated Appendicitis in Children with Autism Spectrum Disorders.Journal of autism and developmental disorders · 2020Article
- [Top ten pediatric radiological emergencies].Der Radiologe · 2020Review
- Fast acquisition abdominal MRI study for the investigation of suspected acute appendicitis in paediatric patients.Insights into imaging · 2020Article
- Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines.World journal of emergency surgery : WJES · 2020Review
- Utility of applying white blood cell cutoffs to non-diagnostic MRI and ultrasound studies for suspected pediatric appendicitis.The American journal of emergency medicine · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Magnetic resonance imaging for the evaluation of appendicitis in children has rapidly increased recently. This change has been primarily driven by the desire to avoid CT radiation dose. This meta-analysis reviews the diagnostic performance of MRI for pediatric appendicitis and discusses current knowledge of cost-effectiveness. We used a conservative Haldane correction statistical method and found pooled diagnostic parameters including a sensitivity of 96.5% (95% confidence interval [CI]: 94.3-97.8%), specificity of 96.1% (95% CI: 93.5-97.7%), positive predictive value of 92.0% (95% CI: 89.3-94.0%) and negative predictive value of 98.3% (95% CI: 97.3-99.0%), based on 11 studies. Assessment of patient outcomes associated with MRI use at two institutions indicates that time to antibiotics was 4.7 h and 8.2 h, time to appendectomy was 9.1 h and 13.9 h, and negative appendectomy rate was 3.1% and 1.4%, respectively. Alternative diagnoses were present in ~20% of cases, most commonly adnexal cysts and enteritis/colitis. Regarding technique, half-acquisition single-shot fast spin-echo (SSFSE) pulse sequences are crucial. While gadolinium-enhanced T1-weighted pulse sequences might be helpful, any benefit beyond non-contrast MRI has not been confirmed. Balanced steady-state free precession (SSFP) sequences are generally noncontributory. Protocols do not need to exceed five sequences; four-sequence protocols are commonly utilized. Sedation generally is not indicated; patients younger than 5 years might be attempted based on the child's ability to cooperate. A comprehensive pediatric cost-effectiveness analysis that includes both direct and indirect costs is needed.
Indexed as
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Registered trials
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