ArticleScientific reports2016
Transcriptome analysis of human ageing in male skin shows mid-life period of variability and central role of NF-κB.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Socioeconomic Inequalities and Molecular Risk for Aging in Young Adulthood.American journal of epidemiology · 2023Pooled it
- The Zinc-Senescence Axis in Skin Aging and Wound Healing: A Narrative Review.International journal of molecular sciences · 2026Review
- Effects of Astraflavonoid A and Astraside C from the Aerial Part ofPlants (Basel, Switzerland) · 2025Article
- Dynamic changes in gene expression through aging in Drosophila melanogaster heads.G3 (Bethesda, Md.) · 2025Article
- The comprehensive assessment of epigenetics changes during skin development.Fundamental research · 2025Article
- Dynamic Changes in Gene Expression Through Aging inbioRxiv : the preprint server for biology · 2024Article
- Development of a biomarker-based platform for comprehensive skin characterization using minimally invasive skin sampling and quantitative real-time PCR.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024Article
- Effects of Age and Sex on the Expression of Core Circadian Clock Genes in Human Skin Epidermis.The Journal of investigative dermatology · 2024Article
- voyAGEr, a free web interface for the analysis of age-related gene expression alterations in human tissues.eLife · 2024Article
- The Short- and Long-Term Outcome Priorities of a Western Australian Adult Burn Population.Journal of burn care & research : official publication of the American Burn Association · 2024Article
- Microneedles: A novel clinical technology for evaluating skin characteristics.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024Article
- The quest to define senescence.Frontiers in genetics · 2024Article
- Article
- Skin pigmentation gradually decreases with age under non-ultraviolet exposure conditions.Skin health and disease · 2023Article
- Poly-D,L-Lactic Acid Filler Increases Extracellular Matrix by Modulating Macrophages and Adipose-Derived Stem Cells in Aged Animal Skin.Antioxidants (Basel, Switzerland) · 2023Article
- Age or lifestyle-induced accumulation of genotoxicity is associated with a length-dependent decrease in gene expression.iScience · 2023Article
- Tideglusib promotes wound healing in aged skin by activating PI3K/Akt pathway.Stem cell research & therapy · 2022Article
- Focus on the Contribution of Oxidative Stress in Skin Aging.Antioxidants (Basel, Switzerland) · 2022Review
- Minimally invasive skin sampling and transcriptome analysis using microneedles for skin type biomarker research.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2022Article
- Systems approaches to investigate the role of NF-κB signaling in aging.The Biochemical journal · 2022Review
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Age is well-known to be a significant factor in both disease pathology and response to treatment, yet the molecular changes that occur with age in humans remain ill-defined. Here, using transcriptome profiling of healthy human male skin, we demonstrate that there is a period of significantly elevated, transcriptome-wide expression changes occurring predominantly in middle age. Both pre and post this period, the transcriptome appears to undergo much smaller, linear changes with increasing age. Functional analysis of the transient changes in middle age suggest a period of heightened metabolic activity and cellular damage associated with NF-kappa-B and TNF signaling pathways. Through meta-analysis we also show the presence of global, tissue independent linear transcriptome changes with age which appear to be regulated by NF-kappa-B. These results suggest that aging in human skin is associated with a critical mid-life period with widespread transcriptome changes, both preceded and proceeded by a relatively steady rate of linear change in the transcriptome. The data provides insight into molecular changes associated with normal aging and will help to better understand the increasingly important pathological changes associated with aging.
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Registered trials
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