ArticleActa neuropathologica communications2016
DNA methylation analysis of paediatric low-grade astrocytomas identifies a tumour-specific hypomethylation signature in pilocytic astrocytomas.
Article in Acta neuropathologica communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Region-specific roles of stress-activated protein kinase MKK7 in the developing and maturing murine brain.Scientific reports · 2025Article
- Transcriptomic Portraits and Molecular Pathway Activation Features of Adult Spinal Intramedullary Astrocytomas.Frontiers in oncology · 2022Article
- Molecular alterations of low-grade gliomas in young patients: Strategies and platforms for routine evaluation.Neuro-oncology practice · 2021Review
- Recent Advances in Pediatric Cancer Research.Cancer research · 2021Review
- Article
- Clinical impact of combined epigenetic and molecular analysis of pediatric low-grade gliomas.Neuro-oncology · 2020Article
- Pilocytic astrocytoma demethylation and transcriptional landscapes link bZIP transcription factors to immune response.Neuro-oncology · 2020Article
- In silico analysis identifies a putative cell-of-origin for BRAF fusion-positive cerebellar pilocytic astrocytoma.PloS one · 2020Article
- MicroRNA profile of pediatric pilocytic astrocytomas identifies two tumor-specific signatures when compared to non-neoplastic white matter.Journal of neuro-oncology · 2019Article
- CCND1 Splice Variant as A Novel Diagnostic and Predictive Biomarker for Thyroid Cancer.Cancers · 2018Article
- Review
- Integrated DNA methylation analysis identifies topographical and tumoral biomarkers in pilocytic astrocytomas.Oncotarget · 2018Article
- Impact of LINE-1 hypomethylation on the clinicopathological and molecular features of colorectal cancer patients.PloS one · 2018Article
- Association between long interspersed nuclear element-1 methylation levels and relapse in Wilms tumors.Clinical epigenetics · 2017Article
Corrections and comments
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Authors and funding
16 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Low-grade gliomas (LGGs) account for about a third of all brain tumours in children. We conducted a detailed study of DNA methylation and gene expression to improve our understanding of the biology of pilocytic and diffuse astrocytomas. Pilocytic astrocytomas were found to have a distinctive signature at 315 CpG sites, of which 312 were hypomethylated and 3 were hypermethylated. Genomic analysis revealed that 182 of these sites are within annotated enhancers. The signature was not present in diffuse astrocytomas, or in published profiles of other brain tumours and normal brain tissue. The AP-1 transcription factor was predicted to bind within 200 bp of a subset of the 315 differentially methylated CpG sites; the AP-1 factors, FOS and FOSL1 were found to be up-regulated in pilocytic astrocytomas. We also analysed splice variants of the AP-1 target gene, CCND1, which encodes cell cycle regulator cyclin D1. CCND1a was found to be highly expressed in both pilocytic and diffuse astrocytomas, but diffuse astrocytomas have far higher expression of the oncogenic variant, CCND1b. These findings highlight novel genetic and epigenetic differences between pilocytic and diffuse astrocytoma, in addition to well-described alterations involving BRAF, MYB and FGFR1.
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