Evidence map›Paper›PMID 27228503›Full record

ReviewJournal of biomedical optics2016

Optical coherence tomography for embryonic imaging: a review.

Raksha Raghunathan, Manmohan Singh, Mary E Dickinson, Kirill V Larin

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of biomedical optics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 75 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Optical Coherence Microscopy for Oocyte Imaging.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Embryonic Mouse Cardiodynamic OCT Imaging.Journal of cardiovascular development and disease · 2020
    Review
  20. Biometric Measurement of Anterior Segment: A Review.Sensors (Basel, Switzerland) · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Raksha RaghunathanUniversity of Houston, Department of Biomedical Engineering, 3517 Cullen Boulevard, Room 2027, Houston, Texas 77204-5060, United States.
Manmohan SinghUniversity of Houston, Department of Biomedical Engineering, 3517 Cullen Boulevard, Room 2027, Houston, Texas 77204-5060, United States.
Mary E DickinsonBaylor College of Medicine, Department of Molecular Physiology and Biophysics, One Baylor Plaza- BCM335, Houston, Texas 77030, United States.
Kirill V LarinUniversity of Houston, Department of Biomedical Engineering, 3517 Cullen Boulevard, Room 2027, Houston, Texas 77204-5060, United StatesbBaylor College of Medicine, Department of Molecular Physiology and Biophysics, One Baylor Plaza- BCM335, Houston, Texas.
Baylor College of Medicine · USUniversity of Houston · US

Funding

Consortium for Broad Based Disease Phenotyping of Knockout MiceU54HG006348 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI BEAUDET, ARTHUR L., PAYLOR, RICHARD E · 2011 to 2015
$17.0M
VISION RESEARCH CENTERP30EY002520 · NEI · BAYLOR COLLEGE OF MEDICINE · PI Samuel M Wu · 1985 to 2026
$14.8M
Optical Coherence Elastography of the CorneaR01EY022362 · NEI · UNIVERSITY OF HOUSTON · PI Salavat R Aglyamov, Kirill V Larin · 2012 to 2026
$6.7M
Optical Coherence Tomography to Study Effect of Poly - Drug Exposure on Fetal Brain DevelopmentR01HD086765 · NICHD · UNIVERSITY OF HOUSTON · PI Kirill V Larin, Irina Larina · 2016 to 2026
$5.0M
Biomechanics of early mammalian cardiogenesisR01HL120140 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI LARINA, IRINA · 2013 to 2017
$2.0M
Phenotyping embryonic mammalian heart function using OCTR01HL095586 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI DICKINSON, MARY E, LARIN, KIRILL V · 2009 to 2012
$1.7M
NEI NIH HHS P30 EY002520NEI NIH HHS R01 EY022362NHGRI NIH HHS U54 HG006348NHLBI NIH HHS R01 HL095586NHLBI NIH HHS R01 HL120140NICHD NIH HHS R01 HD086765
6 · The paper itself

Abstract

Embryogenesis is a highly complex and dynamic process, and its visualization is crucial for understanding basic physiological processes during development and for identifying and assessing possible defects, malformations, and diseases. While traditional imaging modalities, such as ultrasound biomicroscopy, micro-magnetic resonance imaging, and micro-computed tomography, have long been adapted for embryonic imaging, these techniques generally have limitations in their speed, spatial resolution, and contrast to capture processes such as cardiodynamics during embryogenesis. Optical coherence tomography (OCT) is a noninvasive imaging modality with micrometer-scale spatial resolution and imaging depth up to a few millimeters in tissue. OCT has bridged the gap between ultrahigh resolution imaging techniques with limited imaging depth like confocal microscopy and modalities, such as ultrasound sonography, which have deeper penetration but poorer spatial resolution. Moreover, the noninvasive nature of OCT has enabled live imaging of embryos without any external contrast agents. We review how OCT has been utilized to study developing embryos and also discuss advances in techniques used in conjunction with OCT to understand embryonic development.

Indexed as

Tomography, Optical CoherenceAnimalsEmbryo, MammalianEmbryonic DevelopmentEmbryo, NonmammalianMagnetic Resonance ImagingMicroscopy, AcousticMicroscopy, ConfocalX-Ray Microtomography

Identifiers

PMID27228503
PMCPMC4881290
OpenAlexW2398140593

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.