ArticleHuman brain mapping2016
Accelerated longitudinal gray/white matter contrast decline in aging in lightly myelinated cortical regions.
Article in Human brain mapping, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 57 citations in OpenAlex.
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- Cortical gray-white matter contrast alterations precede amyloid-β positivity and macrostructural changes in older adults without dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Reliability of electric field simulations in different age groups: impact of data quality metrics.Brain informatics · 2026Article
- Automated characterization of the gray matter white matter distribution demonstrates age-related decline.Scientific reports · 2026Article
- Changes in brain morphology over the first year in adult mixed-mechanism mild traumatic brain injury: the role of injury severity factors.NeuroImage. Clinical · 2026Article
- Altered cortical myelination based on gray-to-white matter signal intensity contrast in shift workers.Brain structure & function · 2025Article
- Complementary MR measures of white matter and their relation to cardiovascular health and cognition.Scientific reports · 2025Article
- DunedinPACNI estimates the longitudinal Pace of Aging from a single brain image to track health and disease.Nature aging · 2025Article
- An estimate of the longitudinal pace of aging from a single brain scan predicts dementia conversion, morbidity, and mortality.bioRxiv : the preprint server for biology · 2025Article
- Changes in microstructural similarity of hippocampal subfield circuits in pathological cognitive aging.Brain structure & function · 2024Article
- Aging Brain from a Lifespan Perspective.Current topics in behavioral neurosciences · 2024Review
- High spatial overlap but diverging age-related trajectories of cortical magnetic resonance imaging markers aiming to represent intracortical myelin and microstructure.Human brain mapping · 2023Article
- Gray-white matter boundary Z-score and volume as imaging biomarkers of Alzheimer's disease.Frontiers in aging neuroscience · 2023Article
- Cortical gray-white matter contrast abnormalities in male children with attention deficit hyperactivity disorder.Frontiers in human neuroscience · 2023Article
- Telomere length and brain imaging phenotypes in UK Biobank.PloS one · 2023Article
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- Empirical transmit field bias correction of T1w/T2w myelin maps.NeuroImage · 2022Article
- Linking Plasma Amyloid Beta and Neurofilament Light Chain to Intracortical Myelin Content in Cognitively Normal Older Adults.Frontiers in aging neuroscience · 2022Article
- Telomere length is causally connected to brain MRI image derived phenotypes: A mendelian randomization study.PloS one · 2022Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Highly myelinated cortical regions seem to develop early and are more robust to age-related decline. By use of different magnetic resonance imaging (MRI) measures such as contrast between T1- and T2-weighted MRI scans (T1w/T2w) it is now possible to assess correlates of myelin content in vivo. Further, previous studies indicate that gray/white matter contrast (GWC) become blurred as individuals' age, apparently reflecting age-related changes in myelin structure. Here we address whether longitudinal changes in GWC are dependent on initial myelin content within tissue as defined by baseline T1w/T2w contrast, and hypothesize that lightly myelinated regions undergo more decline longitudinally. A sample of 207 healthy adult participants (range: 20-84 years) was scanned twice (interscan interval: 3.6 years). Results showed widespread longitudinal reductions of GWC throughout the cortical surface, especially in the frontal cortices, mainly driven by intensity decay in the white matter. Annual rate of GWC blurring showed acceleration with age in temporal and medial prefrontal regions. Moreover, the anatomical distribution of increased rate of GWC decline with advancing age was strongly related to baseline levels of intracortical myelin. This study provides a first evidence of accelerated regional GWC blurring with advancing age, relates GWC patterns to cortical myeloarchitectonics and supports the hypothesis of increased age-related vulnerability of lightly myelinated areas. Hum Brain Mapp 37:3669-3684, 2016. © 2016 Wiley Periodicals, Inc.
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