Evidence map›Paper›PMID 27228351›Full record

ArticleCell death & disease2016

Long intergenic non-coding RNA APOC1P1-3 inhibits apoptosis by decreasing α-tubulin acetylation in breast cancer.

X-H Liao, J-G Wang, L-Y Li, D-M Zhou, K-H Ren, Y-T Jin, L Lv, J-G Yu, J-Y Yang, Q Lu and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Expression Level of lncRNA CYTOR in Iranian Cervical Cancer Patients.Reports of biochemistry & molecular biology · 2023
    Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Long noncoding RNACell adhesion & migration · 2021
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Apolipoprotein C1: Its Pleiotropic Effects in Lipid Metabolism and Beyond.International journal of molecular sciences · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

X-H LiaoDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, No. 138 Yixueyuan Road, Shanghai, China.
J-G WangDepartment of Pathology, School of Basic Medical Sciences, Fudan University, No. 138 Yixueyuan Road, Shanghai, China.
L-Y LiDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, No. 138 Yixueyuan Road, Shanghai, China.
D-M ZhouDepartment of Pathology, School of Basic Medical Sciences, Fudan University, No. 138 Yixueyuan Road, Shanghai, China.
K-H RenDepartment of Pathology, School of Basic Medical Sciences, Fudan University, No. 138 Yixueyuan Road, Shanghai, China.
Y-T JinDepartment of Breast Surgery, Huashan Hospital, Fudan University, No. 12 Urumqi Middle Road, Shanghai, China.
L LvDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, No. 138 Yixueyuan Road, Shanghai, China.
J-G YuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, No. 138 Yixueyuan Road, Shanghai, China.
J-Y YangDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, No. 138 Yixueyuan Road, Shanghai, China.
Q LuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, No. 138 Yixueyuan Road, Shanghai, China.
Q ZouDepartment of Breast Surgery, Huashan Hospital, Fudan University, No. 12 Urumqi Middle Road, Shanghai, China.
J YuDepartment of Medicine, University of Louisville, Louisville, KY 40292, USA.
X-P LiuDepartment of Pathology, School of Basic Medical Sciences, Fudan University, No. 138 Yixueyuan Road, Shanghai, China.
P ZhouDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, No. 138 Yixueyuan Road, Shanghai, China.
Fudan University · CNShanghai Medical College of Fudan University · CNUniversity of Louisville · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increasing evidence indicates that long non-coding RNAs (lncRNAs) act as important regulatory factors in tumor progression. However, their roles in breast cancer remain largely unknown. In present studies, we identified aberrantly expressed long intergenic non-coding RNA APOC1P1-3 (lincRNA-APOC1P1-3) in breast cancer by microarray, verified it by quantitative real-time PCR, and assessed methylation status in the promoter region by pyrosequencing. We also investigated the biological functions with plasmid transfection and siRNA silencing experiments, and further explored their mechanisms by RNA pull-down and RNA immunoprecipitation to identify binding proteins. We found that 224 lncRNAs were upregulated in breast cancer, whereas 324 were downregulated. The lincRNA-APOC1P1-3 was overexpressed in breast cancer, which was related to tumor size and hypomethylation in its promoter region. We also found that APOC1P1-3 could directly bind to tubulin to decrease α-tubulin acetylation, to inactivate caspase-3, and to inhibit apoptosis. This study demonstrates that overexpression of APOC1P1-3 can inhibit breast cancer apoptosis.

Indexed as

Gene Expression Regulation, NeoplasticAcetylationAdultBreast NeoplasmsCaspase 3Cell Line, TumorCell ProliferationDNA MethylationFemaleGene Expression ProfilingHumansMicroarray AnalysisMiddle AgedNeoplasm StagingPromoter Regions, GeneticRNA, Long NoncodingCASP3 protein, humanCaspase 3RNA, Long NoncodingRNA, Small InterferingTubulin

Identifiers

PMID27228351
PMCPMC4917671
OpenAlexW2394607623

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.