ReviewCurrent opinion in immunology2016
Interplay of innate and adaptive immunity in metal-induced hypersensitivity.
Review in Current opinion in immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 67 citations in OpenAlex.
- Modelling immune gene expression profiles as pharmacodynamic endpoints of antileishmanial treatment.British journal of clinical pharmacology · 2026Article
- Systemic chronic beryllium disease: beyond lung disease.Occupational and environmental medicine · 2026Article
- A Network Toxicology Framework for Identification of Immune System Disruption by Per- and Polyfluoroalkyl Substance (PFAS) Mixture: In Silico Analysis.Journal of xenobiotics · 2026Article
- Heavy metals and prevalence of sexually transmitted infections: a cross-sectional study using data from the National Health and Nutrition Examination Survey (NHANES) 2003-2016.BMC infectious diseases · 2026Article
- Kinetics and Fluid-Specific Behavior of Metal Ions After Hip Replacement.Bioengineering (Basel, Switzerland) · 2025Article
- Particles exposures and sarcoidosis.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2025Article
- Immune impacts of fire smoke exposure.Nature medicine · 2025Article
- The Role of Air Pollution in the Pathogenesis of Atopic Dermatitis, With a Focus on Oxidative Stress.Clinical and translational allergy · 2025Review
- Assessing Heavy Metal Contamination in Food: Implications for Human Health and Environmental Safety.Toxics · 2025Review
- Metal coordination polymer nanoparticles for cancer therapy.Essays in biochemistry · 2025Review
- The Interaction Among Effector, Regulatory, and Tγδ Cells Determines the Development of Allergy or Tolerance to Chromium.Journal of clinical medicine · 2025Article
- Rethinking Biomedical Titanium Alloy Design: A Review of Challenges from Biological and Manufacturing Perspectives.Advanced healthcare materials · 2025Review
- Acidic oral environment's potential contribution to palladium-induced systemic contact dermatitis: Case report.The journal of allergy and clinical immunology. Global · 2024Article
- Metal-coding assisted serological multi-omics profiling deciphers the role of selenium in COVID-19 immunity.Chemical science · 2023Article
- Immune response differences in degradable and non-degradable alloy implants.Bioactive materials · 2023Review
- Article
- The role and mechanism of inflammatory response to growing rod implantation in early onset scoliosis.Frontiers in cell and developmental biology · 2023Review
- NLRP3 inflammasome activation in response to metals.Frontiers in immunology · 2023Review
- Protective role of tissue-resident Tregs in a murine model of beryllium-induced disease.JCI insight · 2022Article
- Metallic Implants Used in Lumbar Interbody Fusion.Materials (Basel, Switzerland) · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Metal-induced hypersensitivity is driven by T cell sensitization to metal ions. Recent advances in our understanding of the complex interactions between innate and adaptive immunity have expanded our knowledge of the pathogenesis of these diseases. Metals activate the innate immune system through direct binding to pathogen recognition receptors, activation of the inflammasome, or the induction of cellular death and release of alarmins. Certain metals can serve as adjuvants, promoting dendritic cell activation and migration as well as antigen presentation to metal-specific T cells. These T cells can recognize metals as haptens or as altered MHC-peptide complexes. The ability of metals to create these neoantigens emphasizes the similarity between metal-induced hypersensitivity and autoimmunity.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.