Observational studyPloS one2016
Serum Malondialdehyde Concentration and Glutathione Peroxidase Activity in a Longitudinal Study of Gestational Diabetes.
Observational study in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- Redox Imbalance in Gestational Diabetes Mellitus: Mechanistic Insights, Emerging Biomarkers, and Therapeutic Perspectives.International journal of molecular sciences · 2026Review
- Pregnancy Under Pressure: Oxidative Stress as a Common Thread in Maternal Disorders.Life (Basel, Switzerland) · 2025Review
- Oxidative Stress in Pregnancy.Biomolecules · 2023Review
- Effects of Mulberry Leaf Fu Tea on the Intestines and Intestinal Flora of Goto-Kakizaki Type 2 Diabetic Rats.Foods (Basel, Switzerland) · 2023Article
- GC-MS and GC-MS/MS measurement of malondialdehyde (MDA) in clinical studies: Pre-analytical and clinical considerations.Journal of mass spectrometry and advances in the clinical lab · 2023Review
- Dietary Implications of Polyunsaturated Fatty Acids during Pregnancy and in Neonates.Life (Basel, Switzerland) · 2023Review
- Antenatal and Postnatal Sequelae of Oxidative Stress in Preterm Infants: A Narrative Review Targeting Pathophysiological Mechanisms.Antioxidants (Basel, Switzerland) · 2023Review
- Ultra-Processed Food Consumption during Pregnancy and Its Association with Maternal Oxidative Stress Markers.Antioxidants (Basel, Switzerland) · 2022Article
- The Effect of Dietary Supplements on Oxidative Stress in Pregnant Women with Gestational Diabetes Mellitus: A Network Meta-Analysis.Nutrients · 2021Article
- Impact of Plasma Oxidative Stress Markers on Post-race Recovery in Ultramarathon Runners: A Sex and Age Perspective Overview.Antioxidants (Basel, Switzerland) · 2021Article
- Associations of Dietary Bioactive Compounds with Maternal Adiposity and Inflammation in Gestational Diabetes: An Update on Observational and Clinical Studies.International journal of environmental research and public health · 2020Review
- Relationship Between Oxidative Stress Markers and Endothelin-1 Levels in Newborns of Different Gestational Ages.Frontiers in pediatrics · 2020Article
- Erythrocyte glucose-6-phosphate dehydrogenase activity and risk of gestational diabetes.Journal of diabetes and metabolic disorders · 2019Article
- Aberrant expression of oxidative stress related proteins affects the pregnancy outcome of gestational diabetes mellitus patients.American journal of translational research · 2019Article
- Prepregnancy Obesity, Maternal Dietary Intake, and Oxidative Stress Biomarkers in the Fetomaternal Unit.BioMed research international · 2019Article
- Influence of gestational diabetes on the activity of δ-aminolevulinate dehydratase and oxidative stress biomarkers.Redox report : communications in free radical research · 2018Article
- Comparisons of the oxidative stress biomarkers levels in gestational diabetes mellitus (GDM) and non-GDM among Thai population: cohort study.Endocrine connections · 2018Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThe main goal of this study was to evaluate the presence of oxidative damage and to quantify its level in gestational diabetes.
methodsThirty-six healthy women and thirty-six women with gestational diabetes were studied in the three trimesters of pregnancy regarding their levels of oxidative stress markers. These women were diagnosed with diabetes in the second trimester of pregnancy. Blood glucose levels after 100g glucose tolerance test were higher than 190, 165 or 145 mg/dl, 1, 2 or 3 hours after glucose intake.
resultsThe group of women with gestational diabetes had higher serum malondialdehyde levels, with significant differences between groups in the first and second trimester. The mean values of serum glutathione peroxidase activity in the diabetic women were significantly lower in the first trimester. In the group of women with gestational diabetes there was a negative linear correlation between serum malondialdehyde concentration and glutathione peroxidase activity in the second and third trimester.
conclusionsIn this observational and longitudinal study in pregnant women, the alterations attributable to oxidative stress were present before the biochemical detection of the HbA1c increase. Usual recommendations once GD is detected (adequate metabolic control, as well as any other normally proposed to these patients) lowered the concentration of malondialdehyde at the end of pregnancy to the same levels of the healthy controls. Serum glutathione peroxidase activity in women with gestational diabetes increased during the gestational period.
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