Evidence map›Paper›PMID 27228055›Full record

ArticleJournal of natural products2016

Synthesis and Antimalarial Activity of Mallatojaponin C and Related Compounds.

Alexander L Eaton, Seema Dalal, M Belen Cassera, Shuqi Zhao, David G I Kingston

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of natural products, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Antimalarial Natural Products.Progress in the chemistry of organic natural products · 2022
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alexander L EatonDepartment of Chemistry and the Virginia Tech Center for Drug Discovery and ‡Department of Biochemistry and the Virginia Tech Center for Drug Discovery, Virginia Tech , Blacksburg, Virginia 24061, United States.
Seema DalalDepartment of Chemistry and the Virginia Tech Center for Drug Discovery and ‡Department of Biochemistry and the Virginia Tech Center for Drug Discovery, Virginia Tech , Blacksburg, Virginia 24061, United States.
M Belen CasseraDepartment of Chemistry and the Virginia Tech Center for Drug Discovery and ‡Department of Biochemistry and the Virginia Tech Center for Drug Discovery, Virginia Tech , Blacksburg, Virginia 24061, United States.
Shuqi ZhaoDepartment of Chemistry and the Virginia Tech Center for Drug Discovery and ‡Department of Biochemistry and the Virginia Tech Center for Drug Discovery, Virginia Tech , Blacksburg, Virginia 24061, United States.
David G I KingstonDepartment of Chemistry and the Virginia Tech Center for Drug Discovery and ‡Department of Biochemistry and the Virginia Tech Center for Drug Discovery, Virginia Tech , Blacksburg, Virginia 24061, United States.

Funding

Discovery and Mechanism of Antimalarial Natural ProductsR01AT008088 · NCCIH · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI CASSERA, MARIA BELEN, CLEMENT, JASON ANDERSON · 2014 to 2018
$2.0M
NCCIH NIH HHS R01 AT008088
6 · The paper itself

Abstract

The phloroglucinol mallotojaponin C (1) from Mallotus oppositifolius, which was previously shown by us to have both antiplasmodial and cytocidal activities against the malaria parasite Plasmodium falciparum, was synthesized in three steps from 2',4',6'-trihydroxyacetophenone, and various derivatives were synthesized in an attempt to improve the bioactivity of this class of compounds. Two derivatives, the simple prenylated phloroglucinols 12 and 13, were found to have comparable antiplasmodial activities to that of mallotojaponin C.

Indexed as

AnimalsAntimalarialsMallotus PlantMolecular StructurePhloroglucinolPlasmodium falciparumAntimalarialsmallotojaponin CPhloroglucinol

Identifiers

PMID27228055
PMCPMC4924580

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.