Evidence map›Paper›PMID 27227930›Full record

Trial reportMedicine2016

Perioperative Standard Oral Nutrition Supplements Versus Immunonutrition in Patients Undergoing Colorectal Resection in an Enhanced Recovery (ERAS) Protocol: A Multicenter Randomized Clinical Trial (SONVI Study).

Pedro Moya, Leticia Soriano-Irigaray, Jose Manuel Ramirez, Alessandro Garcea, Olga Blasco, Francisco Javier Blanco, Carlo Brugiotti, Elena Miranda, Antonio Arroyo

5 registry-linked trialsOpen access · goldAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 58 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 15 pooled it
10.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02393976 nacompletednot on this map

Nutritional effects and influence in the morbidity and mortality of diet immunomodulatory in fast-track surgery

TypeinterventionalSponsorHospital General Universitario ElcheRan2014 to 2015Enrolled120ConditionsIMMUNONUTRITIONArmsIMMUNONUTRITION, STANDART NUTRITION
NCT03803280 unknown statusnot on this map

Implementation of the Enhanced Recovery in Abdominal Surgery Pathway in the National Health Network (IMPRICA Project)

TypeobservationalSponsorGrupo Español de Rehabilitación MultimodalRan2016 to 2022Enrolled2,000ConditionsMajor SurgeryArmsERAS program
NCT04059731 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Randomized, Multicentric, Double-blind, Controlled Trial of Parallel Groups to Evaluate the Non-inferiority of a Postoperative Diet With an Oligomeric-hyperprotein-normocaloric Versus Imunonutrients After Surgery for Colorectal Cancer.

TypeinterventionalSponsorHospital General Universitario Reina Sofía de MurciaRan2019 to 2020Enrolled108ConditionsNutrition Related Neoplasm/Cancer, Colorectal Cancer, Surgery--Complications, Site InfectionArmsNutrition supplement
NCT05568316 nacompletednot on this mapstarted 2020, after this paper: background citation

Impact of Immunonutrition on Nutritional Status in Patients Undergoing Colorectal Cancer Surgery: A Randomised Controlled Clinical Trial

TypeinterventionalSponsorSaglik Bilimleri UniversitesiRan2020 to 2022Enrolled50ConditionsColorectal CancerArmsPreoperative Immunonutrition, Perioperative Immunonutrition
NCT06103526 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Immunonutrition and Enhanced Recovery After Surgery Protocols in Gynecologic Oncology

TypeinterventionalSponsorNational and Kapodistrian University of AthensRan2023 to 2025Enrolled200ConditionsNutritional Deficiency, Gynecologic Cancer, ERASArmsImmunonutrition
3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 15 syntheses or guidelines pooled it, 146 citations in OpenAlex.

  1. Pooled it
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  8. The use of preoperative enteral immunonutrition in patients undergoing elective colorectal cancer surgery: A systematic review and meta-analysis.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2025
    Pooled it
  9. Guideline
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  14. Effect of Perioperative Nutritional Supplementation on Postoperative Complications-Systematic Review and Meta-Analysis.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2019
    Pooled it
  15. Pooled it
  16. Trial
  17. Perioperative immunonutrition intervention on postoperative outcomes among gynaecological cancer patients under enhanced recovery after surgery setting.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Pedro MoyaFrom the Department of General Surgery (PM, AA), Division of Colorectal Surgery, University General Hospital of Elche, Elche; Department of Hospital Pharmacy (LS-I), University General Hospital of Elche, Elche; Department of General Surgery (JMR), Division of Colorectal Surgery, University Clinic Hospital Lozano Blesa, Zaragoza; Department of General Surgery (AG), Division of Colorectal Surgery, Hospital of Torrevieja, Torrevieja; Department of General Surgery (OB), Division of Colorectal Surgery, Virgen del Puerto Hospital, Plasencia; Department of General Surgery (FJB), Division of Colorectal Surgery, University Hospital of La Ribera, Alzira; Department of General Surgery (CB), Division of Colorectal Surgery, Hospital of Manacor, Manacor; and Department of Anesthesia (EM), University General Hospital of Elche, Elche, Spain.
Leticia Soriano-Irigaray
Jose Manuel Ramirez
Alessandro Garcea
Olga Blasco
Francisco Javier Blanco
Carlo Brugiotti
Elena Miranda
Antonio Arroyo
Fundación Hospital Manacor · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To compare immunonutrition versus standard high calorie nutrition in patients undergoing elective colorectal resection within an Enhanced Recovery After Surgery (ERAS) program.Despite progress in recent years in the surgical management of patients with colorectal cancer (ERAS programs), postoperative complications are frequent. Nutritional supplements enriched with immunonutrients have recently been introduced into clinical practice. However, the extent to which the combination of ERAS protocols and immunonutrition benefits patients undergoing colorectal cancer surgery is unknown.The SONVI study is a prospective, multicenter, randomized trial with 2 parallel treatment groups receiving either the study product (an immune-enhancing feed) or the control supplement (a hypercaloric hypernitrogenous supplement) for 7 days before colorectal resection and 5 days postoperatively.A total of 264 patients were randomized. At baseline, both groups were comparable in regards to age, sex, surgical risk, comorbidity, and analytical and nutritional parameters. The median length of the postoperative hospital stay was 5 days with no differences between the groups. A decrease in the total number of complications was observed in the immunonutrition group compared with the control group, primarily due to a significant decrease in infectious complications (23.8% vs. 10.7%, P = 0.0007). Of the infectious complications, wound infection differed significantly between the groups (16.4% vs. 5.7%, P = 0.0008). Other infectious complications were lower in the immunonutrition group but were not statistically significantly different.The implementation of ERAS protocols including immunonutrient-enriched supplements reduces the complications of patients undergoing colorectal resection.This study is registered with ClinicalTrial.gov: NCT02393976.

Indexed as

Clinical ProtocolsDietary SupplementsAdultAgedAged, 80 and overColorectal NeoplasmsColorectal SurgeryFemaleHumansLength of StayMaleMiddle AgedPerioperative CarePostoperative ComplicationsProspective StudiesSpain

Identifiers

PMID27227930
PMCPMC4902354
OpenAlexW2398385570

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.