Evidence map›Paper›PMID 27227921›Full record

ArticleMedicine2016

Cost-Effectiveness and Quality of Care of a Comprehensive ART Program in Malawi.

Stefano Orlando, Samantha Diamond, Leonardo Palombi, Maaya Sundaram, Lauren Shear Zimmer, Maria Cristina Marazzi, Sandro Mancinelli, Giuseppe Liotta

Erratum issuedAbstract read
In one paragraph

Article in Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Differentiated Human Immunodeficiency Virus RNA Monitoring in Resource-Limited Settings: An Economic Analysis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017
    Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Stefano OrlandoFrom the Dream programme - Community of Sant'Egidio (SO), Clinton Health Access Initiative (SD, LSZ), Department of Public Health, University of Tor Vergata, Rome, Italy (LP, SM, GL), Bill and Melinda Gates Foundation (MS), and LUMSA University, Rome, Italy (MCM).
Samantha Diamond
Leonardo Palombi
Maaya Sundaram
Lauren Shear Zimmer
Maria Cristina Marazzi
Sandro Mancinelli
Giuseppe Liotta

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study is to assess the cost-effectiveness of a holistic, comprehensive human immunodeficiency virus (HIV) treatment Program in Malawi.Comprehensive cost data for the year 2010 have been collected at 30 facilities from the public network of health centers providing antiretroviral treatment (ART) throughout the country; two of these facilities were operated by the Disease Relief through Excellent and Advanced Means (DREAM) program.The outcomes analysis was carried out over five years comparing two cohorts of patients on treatment: 1) 2387 patients who started ART in the two DREAM centers during 2008, 2) patients who started ART in Malawi in the same year under the Ministry of Health program.Assuming the 2010 cost as constant over the five years the cost-effective analysis was undertaken from a health sector and national perspective; a sensitivity analysis included two hypothesis of ART impact on patients' income.The total cost per patient per year (PPPY) was $314.5 for the DREAM protocol and $188.8 for the other Malawi ART sites, with 737 disability adjusted life years (DALY) saved among the DREAM program patients compared with the others. The Incremental Cost-Effectiveness Ratio was $1640 per DALY saved; it ranged between $896-1268 for national and health sector perspective respectively. The cost per DALY saved remained under $2154 that is the AFR-E-WHO regional gross domestic product per capita threshold for a program to be considered very cost-effective.HIV/acquired immune deficiency syndrome comprehensive treatment program that joins ART with laboratory monitoring, treatment adherence reinforcing and Malnutrition control can be very cost-effective in the sub-Saharan African setting.

Indexed as

Anti-HIV AgentsCD4 Lymphocyte CountCost-Benefit AnalysisDietary SupplementsHealth ExpendituresHIV InfectionsHumansMedication AdherenceMonitoring, PhysiologicPatient Care ManagementPatient Education as TopicQuality-Adjusted Life YearsQuality of Health CareViral LoadAnti-HIV Agents

Identifiers

PMID27227921
PMCPMC4902345

What OpenQuestion holds

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LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.