Evidence map›Paper›PMID 27227898›Full record

ArticlePloS one2016

Characterization of Three Venom Peptides from the Spitting Spider Scytodes thoracica.

Nathanial K Ariki, Lisa E Muñoz, Elizabeth L Armitage, Francesca R Goodstein, Kathryn G George, Vanessa L Smith, Irina Vetter, Volker Herzig, Glenn F King, Nikolaus M Loening

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Nathanial K ArikiChemistry Department, Lewis & Clark College, 0615 SW Palatine Hill Road, Portland, OR, 97219, United States of America.
Lisa E MuñozChemistry Department, Lewis & Clark College, 0615 SW Palatine Hill Road, Portland, OR, 97219, United States of America.
Elizabeth L ArmitageChemistry Department, Lewis & Clark College, 0615 SW Palatine Hill Road, Portland, OR, 97219, United States of America.
Francesca R GoodsteinChemistry Department, Lewis & Clark College, 0615 SW Palatine Hill Road, Portland, OR, 97219, United States of America.
Kathryn G GeorgeChemistry Department, Lewis & Clark College, 0615 SW Palatine Hill Road, Portland, OR, 97219, United States of America.
Vanessa L SmithChemistry Department, Lewis & Clark College, 0615 SW Palatine Hill Road, Portland, OR, 97219, United States of America.
Irina VetterInstitute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia.
Volker HerzigInstitute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia.
Glenn F KingInstitute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia.
Nikolaus M LoeningChemistry Department, Lewis & Clark College, 0615 SW Palatine Hill Road, Portland, OR, 97219, United States of America.
Lewis & Clark College · USUniversity of Queensland · AU

Funding

Structural Studies and Char. of Neurotoxic Venom Peptides from Sicariidae SpidersR15GM085733 · NIGMS · LEWIS AND CLARK COLLEGE · PI LOENING, NIKOLAUS MARTIN · 2008 to 2012
$433k
NIGMS NIH HHS R15 GM085733
6 · The paper itself

Abstract

We present the solution-state NMR structures and preliminary functional characterizations of three venom peptides identified from the spitting spider Scytodes thoracica. Despite little sequence identity to other venom peptides, structural characterization reveals that these peptides contain an inhibitor cystine knot motif common to many venom peptides. These are the first structures for any peptide or protein from spiders of the Scytodidae family. Many venom peptides target neuronal ion channels or receptors. However, we have not been able to determine the target of these Scytodes peptides so we can only state with certainty the channels and receptors that they do not target.

Indexed as

Amino Acid SequenceAnimalsCystine Knot MotifsGryllidaeModels, MolecularPeptide FragmentsPredatory BehaviorProtein ConformationSalivaSequence Homology, Amino AcidSpidersSpider VenomsThoracicaPeptide FragmentsSpider Venoms

Identifiers

PMID27227898
PMCPMC4881942
OpenAlexW2403055362

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.