ArticlePloS one2016
Amide Proton Transfer Imaging of Diffuse Gliomas: Effect of Saturation Pulse Length in Parallel Transmission-Based Technique.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Endogenous Chemical Exchange Saturation Transfer MRI for the Diagnosis and Therapy Response Assessment of Brain Tumors: A Systematic Review.Radiology. Imaging cancer · 2020Pooled it
- Amide proton transfer-weighted MRI in distinguishing high- and low-grade gliomas: a systematic review and meta-analysis.Neuroradiology · 2019Pooled it
- Chemical exchange saturation transfer MRI for neurodegenerative diseases: An update on clinical and preclinical studies.Neural regeneration research · 2026Article
- 18F-Fluciclovine PET enables accurate and safe resection of malignant brain tumors: illustrative cases.Journal of neurosurgery. Case lessons · 2025Article
- Dynamic glucose-enhanced MRI of gliomas: A preliminary clinical application.NMR in biomedicine · 2025Article
- Unraveling contributions to the Z-spectrum signal at 3.5 ppm of human brain tumors.Magnetic resonance in medicine · 2024Article
- Effect of Saturation Pulse Duration and Power on pH-weighted Amide Proton Transfer Imaging: A Phantom Study.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2023Article
- Only-train-once MR fingerprinting for BMagnetic resonance in medicine · 2023Article
- Review and consensus recommendations on clinical APT-weighted imaging approaches at 3T: Application to brain tumors.Magnetic resonance in medicine · 2022Review
- Learning-based optimization of acquisition schedule for magnetization transfer contrast MR fingerprinting.NMR in biomedicine · 2022Article
- Amide proton transfer imaging for differentiation of tuberculomas from high-grade gliomas: Preliminary experience.The neuroradiology journal · 2021Article
- Non-invasive Differentiation of Endometrial Adenocarcinoma from Benign Lesions in the Uterus by Utilization of Amide Proton Transfer-Weighted MRI.Molecular imaging and biology · 2021Article
- A fast multislice sequence for 3D MRI-CEST pH imaging.Magnetic resonance in medicine · 2021Article
- Prospective acceleration of parallel RF transmission-based 3D chemical exchange saturation transfer imaging with compressed sensing.Magnetic resonance in medicine · 2019Article
- APT-weighted MRI: Techniques, current neuro applications, and challenging issues.Journal of magnetic resonance imaging : JMRI · 2019Review
- Histogram analysis of amide proton transfer-weighted imaging: comparison of glioblastoma and solitary brain metastasis in enhancing tumors and peritumoral regions.European radiology · 2019Article
- Amide proton transfer imaging of tumors: theory, clinical applications, pitfalls, and future directions.Japanese journal of radiology · 2019Review
- Influences of experimental parameters on chemical exchange saturation transfer (CEST) metrics of brain tumors using animal models at 4.7T.Magnetic resonance in medicine · 2019Article
- CEST, ASL, and magnetization transfer contrast: How similar pulse sequences detect different phenomena.Magnetic resonance in medicine · 2018Review
- Quantitative pulsed CEST-MRI at a clinical 3T MRI system.Magma (New York, N.Y.) · 2017Article
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Authors and funding
11 authors.
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Abstract
In this study, we evaluated the dependence of saturation pulse length on APT imaging of diffuse gliomas using a parallel transmission-based technique. Twenty-two patients with diffuse gliomas (9 low-grade gliomas, LGGs, and 13 high-grade gliomas, HGGs) were included in the study. APT imaging was conducted at 3T with a 2-channel parallel transmission scheme using three different saturation pulse lengths (0.5 s, 1.0 s, 2.0 s). The 2D fast spin-echo sequence was used for imaging. Z-spectrum was obtained at 25 frequency offsets from -6 to +6 ppm (step 0.5 ppm). A point-by-point B0 correction was performed with a B0 map. Magnetization transfer ratio (MTRasym) and ΔMTRasym (contrast between tumor and normal white matter) at 3.5 ppm were compared among different saturation lengths. A significant increase in MTRasym (3.5 ppm) of HGG was found when the length of saturation pulse became longer (3.09 ± 0.54% at 0.5 s, 3.83 ± 0.67% at 1 s, 4.12 ± 0.97% at 2 s), but MTRasym (3.5 ppm) was not different among the saturation lengths in LGG. ΔMTRasym (3.5 ppm) increased with the length of saturation pulse in both LGG (0.48 ± 0.56% at 0.5 s, 1.28 ± 0.56% at 1 s, 1.88 ± 0.56% at 2 s and HGG (1.72 ± 0.54% at 0.5 s, 2.90 ± 0.49% at 1 s, 3.83 ± 0.88% at 2 s). In both LGG and HGG, APT-weighted contrast was enhanced with the use of longer saturation pulses.
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