Evidence map›Paper›PMID 27227701›Full record

ArticlePsychiatry research2016

Inflammatory cytokines and nuclear factor-kappa B activation in adolescents with bipolar and major depressive disorders.

David J Miklowitz, Larissa C Portnoff, Casey C Armstrong, Danielle Keenan-Miller, Elizabeth C Breen, Keely A Muscatell, Naomi I Eisenberger, Michael R Irwin

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychiatry research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01483391 (Early Intervention for Youth at Risk for Bipolar Disorder), which is not on this map. Cited by 49 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 2 pooled it
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01483391 nacompletednot on this map

Early Intervention for Youth at Risk for Bipolar Disorder

TypeinterventionalSponsorUniversity of California, Los AngelesRan2011 to 2020Enrolled150ConditionsBipolar Disorder, Major Depressive DisorderArmsEnhanced Care, Family-Focused Treatment
3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 2 syntheses or guidelines pooled it, 106 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

David J MiklowitzSemel Institute for Neuroscience and Behavior, University of California, Los Angeles (UCLA) School of Medicine, Los Angeles, CA, USA. Electronic address: dmiklowitz@mednet.ucla.edu.
Larissa C PortnoffSemel Institute for Neuroscience and Behavior, University of California, Los Angeles (UCLA) School of Medicine, Los Angeles, CA, USA.
Casey C ArmstrongSemel Institute for Neuroscience and Behavior, University of California, Los Angeles (UCLA) School of Medicine, Los Angeles, CA, USA.
Danielle Keenan-MillerDepartment of Psychology, UCLA, Los Angeles, CA, USA.
Elizabeth C BreenSemel Institute for Neuroscience and Behavior, University of California, Los Angeles (UCLA) School of Medicine, Los Angeles, CA, USA; Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Behavior, UCLA, Los Angeles, CA, USA.
Keely A MuscatellDepartment of Psychology, University of California, Berkeley, CA, USA.
Naomi I EisenbergerDepartment of Psychology, UCLA, Los Angeles, CA, USA; Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Behavior, UCLA, Los Angeles, CA, USA.
Michael R IrwinSemel Institute for Neuroscience and Behavior, University of California, Los Angeles (UCLA) School of Medicine, Los Angeles, CA, USA; Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Behavior, UCLA, Los Angeles, CA, USA.
University of California, Los Angeles · USUniversity of California, Berkeley · US

Funding

1/2-Early Intervention for Youth at Risk for Bipolar DisorderR01MH093676 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MIKLOWITZ, DAVID JAY · 2012 to 2016
$3.6M
Family-Focused Therapy for Youth with Early-Onset Bipolar or Psychotic Disorders R33MH097007 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MIKLOWITZ, DAVID JAY · 2014 to 2016
$853k
Family-Focused Treatment for Youth with Early-Onset Bipolar or Psychotic DisorderR21MH097007 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MIKLOWITZ, DAVID JAY · 2012 to 2013
$439k
NIMH NIH HHS R01 MH093676NIMH NIH HHS R21 MH097007NIMH NIH HHS R33 MH097007
6 · The paper itself

Abstract

unlabelledAdults with bipolar disorder (BD) and major depressive disorder (MDD) have higher circulating levels of proinflammatory cytokines than healthy controls. However, it is not known whether pediatric-onset patients with BD or MDD show increases in levels of inflammation or activation of nuclear factor kappa B (NF-κB), a key transcription factor in inflammatory signaling. Circulating levels of inflammatory cytokines, as well as spontaneous and stimulated levels of activated NF-κB in total peripheral blood mononuclear cells, monocytes and lymphocytes were measured in adolescents with BD (n=18), MDD (n=13), or no psychiatric history (n=20). Participants had a range of mood symptoms at time of testing. Adolescents with BD had significantly higher spontaneous levels of NF-κB in peripheral blood mononuclear cells, monocyte and lymphocyte populations, and higher plasma levels of IL-1β than healthy controls. Following stimulation with recombinant human TNF-α, participants with BD and MDD both had greater increases in NF-κB in monocytes than controls. Further, greater stimulated increases of NF-κB in monocytes were associated with the current severity of depressive symptoms. The results are limited by the small sample and cross-sectional design. Interventions that target early immunological dysregulation should be examined in relation to long-term outcomes in youth with bipolar and depressive disorders. CLINICAL TRIAL REGISTRATION INFORMATION: Early Intervention for Youth at Risk for Bipolar Disorder, https://clinicaltrials.gov/ct2/show/NCT01483391.

Indexed as

AdolescentBipolar DisorderCase-Control StudiesCross-Sectional StudiesCytokinesFemaleHumansInflammationInterleukin-1betaLeukocytes, MononuclearLymphocyte CountMajor Depressive DisorderMaleMonocytesNF-kappa BSignal TransductionCytokinesInterleukin-1betaNF-kappa BTumor Necrosis Factor-alphaInflammationInflammatory signalingInterleukin-1LymphocytesMonocytesNF-ΚBPeripheral blood mononuclear cells

Identifiers

PMID27227701
PMCPMC4912920
OpenAlexW2346699692

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.