ArticlePain2016
Adolescent context of exposure to prescription opioids and substance use disorder symptoms at age 35: a national longitudinal study.
Article in Pain, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
56 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.
- Health harms of non-medical prescription opioid use: A systematic review.Drug and alcohol review · 2022Pooled it
- Article
- Non-medical opioid (NMO) use in Canadian adolescents: Trends, risk factors, and regional variations.Canadian journal of public health = Revue canadienne de sante publique · 2026Article
- Maturing out or in? Demographic determinants of young adult drinking trajectories and midlife alcohol use disorder risks.Alcohol, clinical & experimental research · 2026Article
- Preferences and predictors driving opioid-involved polysubstance use profiles and trajectories: a prospective cohort study protocol.BMJ open · 2025Article
- Use of bupivacaine liposomal injectable suspension in children aged 2 to 6 years undergoing cardiac surgery does not accelerate recovery.JTCVS open · 2025Article
- Adolescent morphine exposure does not alter low-dose lipopolysaccharide (LPS)-induced sickness behavior in adult C57/BL6 mice.PloS one · 2025Article
- Evaluating the Clinical Utility of Brachial Plexus Block for Reducing Opioid Exposure in Pediatric Elbow Fracture Surgery: A Retrospective Cohort Study.Medicina (Kaunas, Lithuania) · 2024Article
- Prevalence of chronic pain or analgesic use in children and young people and its long-term impact on substance misuse, mental illness, and prescription opioid use: a retrospective longitudinal cohort study.The Lancet regional health. Europe · 2023Article
- Examining the Critical Need for Tailored Adolescent Opioid Education: A National Study.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2023Article
- Spatial and temporal trends in the diagnosis of opioid-related problems in commercially-insured adolescents and young adults.Preventive medicine · 2022Article
- Risk factors associated with recent opioid-related hospitalizations in children: a nationwide analysis.Pediatric surgery international · 2022Article
- Are American Indian/Alaska Native Adolescent Health Behaviors Different? A Review of AI/AN Youth Involved in Native STAND Curriculum, 2014-2017 United States.Maternal and child health journal · 2021Review
- Associations between insufficient sleep and prescription opioid misuse among high school students in the United States.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021Article
- Race, Ethnicity, and Insurance: the Association with Opioid Use in a Pediatric Hospital Setting.Journal of racial and ethnic health disparities · 2021Article
- Pediatric Urologic Surgery: Reducing Opioid Use.Paediatric drugs · 2021Article
- Racial and ethnic disparities in opioid use for adolescents at US emergency departments.BMC pediatrics · 2021Article
- Trajectories of Opioid Use Following First Opioid Prescription in Opioid-Naive Youths and Young Adults.JAMA network open · 2021Article
- Social Learning and Addiction.Behavioural brain research · 2021Review
- Prescription drug misuse, other substance use, and sexual identity: The significance of educational status and psychological distress in US young adults.Substance abuse · 2021Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The objective of this study was to examine the association of context of prescription opioid exposure (ie, medical or nonmedical) in adolescence with the subsequent risk of nonmedical use of prescription opioids (NMUPO) and substance use disorder (SUD) symptoms at age 35. Multiple cohorts of nationally representative probability samples of U.S. high school seniors (n = 4072) were surveyed through self-administered questionnaires and followed longitudinally from adolescence (modal age 18, graduating classes 1976-1996) to age 35 (1993-2013). Main outcome measures were past-year NMUPO and SUD symptoms. The medical and NMUPO during adolescence was significantly associated with NMUPO at age 35. Relative to no prescription opioid exposure, medical use of prescription opioids without any history of NMUPO during adolescence was not associated with SUD symptoms at age 35. In contrast, compared with no prescription opioid exposure during adolescence, the adjusted odds ratios (AORs) associated with SUD symptoms at age 35 were greater among those with a history of both medical use of prescription opioids and NMUPO during adolescence, AOR = 1.49 (95% CI = 1.13-1.97); and among those who reported NMUPO only, AOR = 2.61 (95% CI = 1.88-3.61). The findings indicate medical use of prescription opioids without any history of NMUPO in adolescence is not associated with SUD symptoms at age 35, whereas any NMUPO in adolescence predicts SUD symptoms at age 35. Screening instruments and preventive intervention programs to reduce NMUPO and SUDs must account for the context associated with prescription opioid exposure during adolescence.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.