ArticlePloS one2016
Stability and Change in Genetic and Environmental Influences on Well-Being in Response to an Intervention.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Who benefits from mobile health interventions? A dynamical systems analysis of psychological well-being in early adults.Applied psychology. Health and well-being · 2025Trial
- Genetic and phenotypic insights into shell integrity and market traits in farmed Pacific oysters.Scientific reports · 2025Article
- Virtual Reality Mental Health Interventions in Geriatric Care for Functional or Well-being Enhancement - A Scoping Review.Die Rehabilitation · 2024Article
- The Challenges and Opportunities for Mental Health Twin Research in Nigeria.Behavior genetics · 2024Article
- Twins and Causal Inference: Leveraging Nature's Experiment.Cold Spring Harbor perspectives in medicine · 2021Review
- Genome-wide analyses of psychological resilience in U.S. Army soldiers.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2019Article
- Evaluation of the causal effects between subjective wellbeing and cardiometabolic health: mendelian randomisation study.BMJ (Clinical research ed.) · 2018Article
- Moderators of wellbeing interventions: Why do some people respond more positively than others?PloS one · 2017Article
- Online Positive Interventions to Promote Well-being and Resilience in the Adolescent Population: A Narrative Review.Frontiers in psychiatry · 2017Article
- Transforming Life: A Broad View of the Developmental Origins of Health and Disease Concept from an Ecological Justice Perspective.International journal of environmental research and public health · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Genetic and environmental influences on complex traits can change in response to developmental and environmental contexts. Here we explore the impact of a positive activity intervention on the genetic and environmental influences on well-being and mental health in a sample of 750 adolescent twins. Twins completed a 10-week online well-being intervention, consisting of kindness and gratitude tasks and matched control activities. The results showed significant improvements both in well-being and in internalizing symptoms in response to the intervention activities. We used multivariate twin analyses of repeated measures, tracking stability and change in genetic and environmental influences, to assess the impact of this environmental intervention on these variance components. The heritability of well-being remained high both before and after the intervention, and the same genetic effects were important at each stage, even as well-being increased. The overall magnitude of environmental influences was also stable across the intervention; however, different non-shared environmental influences emerged during the intervention. Our study highlights the value of exploring the innovations in non-shared environmental influences that could provide clues to the mechanisms behind improvements in well-being. The findings also emphasize that even traits strongly influenced by genetics, like well-being, are subject to change in response to environmental interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.