Evidence map›Paper›PMID 27227310›Full record

ReviewMicrobiology spectrum2016

The Versatile Type VI Secretion System.

Christopher J Alteri, Harry L T Mobley

Abstract readReview
In one paragraph

Review in Microbiology spectrum, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed.

  1. Article
  2. Review
  3. Interaction of the SXT/R391 element ICEMicrobiology spectrum · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. The Anti-Listeria Activity ofPathogens (Basel, Switzerland) · 2023
    Article
  12. Article
  13. Article
  14. Into the understanding the multicellular lifestyle ofFrontiers in cellular and infection microbiology · 2022
    Review
  15. Article
  16. Colistin Dependence in Extensively Drug-ResistantInternational journal of molecular sciences · 2021
    Article
  17. Review
  18. Bioinformatic Analysis of theFrontiers in microbiology · 2021
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Christopher J AlteriDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109.
Harry L T MobleyDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109.

Funding

Reciprocal Control of Motility and Adherence in UTIR01AI059722 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PEARSON, MELANIE M. · 2005 to 2024
$7.4M
NIAID NIH HHS R01 AI059722
6 · The paper itself

Abstract

Bacterial type VI secretion systems (T6SSs) function as contractile nanomachines to puncture target cells and deliver lethal effectors. In the 10 years since the discovery of the T6SS, much has been learned about the structure and function of this versatile protein secretion apparatus. Most of the conserved protein components that comprise the T6SS apparatus itself have been identified and ascribed specific functions. In addition, numerous effector proteins that are translocated by the T6SS have been identified and characterized. These protein effectors usually represent toxic cargoes that are delivered by the attacker cell to a target cell. Researchers in the field are beginning to better understand the lifestyle or physiology that dictates when bacteria normally express their T6SS. In this article, we consider what is known about the structure and regulation of the T6SS, the numerous classes of antibacterial effector T6SS substrates, and how the action of the T6SS relates to a given lifestyle or behavior in certain bacteria.

Indexed as

Anti-Bacterial AgentsBacteriaBacterial ProteinsBiofilmsMicrobial InteractionsType VI Secretion SystemsAnti-Bacterial AgentsBacterial ProteinsType VI Secretion Systems

Identifiers

PMID27227310
PMCPMC4887148

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.