Evidence map›Paper›PMID 27227168›Full record

ArticleTomography (Ann Arbor, Mich.)2016

Non-invasive differentiation of benign renal tumors from clear cell renal cell carcinomas using clinically translatable hyperpolarized

Renuka Sriram, Mark Van Criekinge, Justin DeLos Santos, Kayvan R Keshari, David M Wilson, Donna Peehl, John Kurhanewicz, Zhen J Wang

Open access · goldAbstract read
In one paragraph

Article in Tomography (Ann Arbor, Mich.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. Hyperpolarized [1-Brain communications · 2025
    Article
  3. Review
  4. Multinuclear MRI in Drug Discovery.Molecules (Basel, Switzerland) · 2022
    Review
  5. Review
  6. HyperpolarizedCancers · 2022
    Article
  7. Specialized computational methods for denoising, BMagnetic resonance in medicine · 2021
    Article
  8. Article
  9. Hyperpolarized Carbon (Methods in molecular biology (Clifton, N.J.) · 2021
    Article
  10. Review
  11. Article
  12. HyperpolarizedOncotarget · 2019
    Article
  13. Review
  14. Article
  15. HyperpolarizedRadiology · 2019
    Review
  16. HyperpolarizedNeoplasia (New York, N.Y.) · 2019
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Renuka SriramRadiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States.
Mark Van CriekingeRadiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States.
Justin DeLos SantosRadiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States.
Kayvan R KeshariRadiology and Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, United States.
David M WilsonRadiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States.
Donna PeehlDepartment of Urology, Stanford University, Stanford, CA, United States.
John KurhanewiczRadiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States.
Zhen J WangRadiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States.
University of California, San Francisco · USUniversity of California System · USMemorial Sloan Kettering Cancer Center · USStanford University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
TR&D3: Open-Source Tools for Processing Hyperpolarized MR DataP41EB013598 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DUAN XU · 2011 to 2026
$19.9M
Development and Translation of Hyperpolarized C-13 Prostate Cancer MRI MethodsR01EB017449 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KURHANEWICZ, JOHN, VIGNERON, DANIEL B · 2013 to 2017
$5.9M
Translating HP 13C MRI as a Novel Paradigm for Assessing Drug Target InhibitionR01CA183071 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HURD, RALPH EUGENE, MUNSTER, PAMELA N. · 2014 to 2018
$3.3M
Novel Hyperpolarized MR Markers of Advanced Prostate Cancer TherapyR01CA166655 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KURHANEWICZ, JOHN, VIGNERON, DANIEL B · 2012 to 2016
$3.0M
New Instrumentation and Techniques for Hyperpolarized Metabolic and Perfusion MRIR01EB013427 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KURHANEWICZ, JOHN, VIGNERON, DANIEL B · 2013 to 2016
$2.8M
Ascorbate-based biomarkers for predicting radiation response in prostate cancerR01CA166766 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WILSON, DAVID M · 2012 to 2016
$2.4M
Hyperpolarized 13c NMR Studies of Prostate Cancer (RMI)R21EB005363 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KURHANEWICZ, JOHN · 2005 to 2008
$1.5M
Hyperpolarized 13C Markers of Diabetic Nephropathy and Treatment ResponseR01DK097357 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WANG, ZHEN JANE · 2013 to 2017
$1.2M
Human Tissue Culture Bioreactor and Hyperpolarized MR for Biomarker DiscoveryR00EB014328 · NIBIB · SLOAN-KETTERING INST CAN RESEARCH · PI KESHARI, KAYVAN R · 2013 to 2015
$735k
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA166655NCI NIH HHS R01 CA166766NCI NIH HHS R01 CA183071NIBIB NIH HHS P41 EB013598NIBIB NIH HHS R00 EB014328NIBIB NIH HHS R01 EB013427NIBIB NIH HHS R01 EB017449NIBIB NIH HHS R21 EB005363NIDDK NIH HHS R01 DK097357
6 · The paper itself

Abstract

Localized renal tumors are increasingly detected incidentally at imaging. Conventional imaging cannot reliably differentiate the 20% of these tumors that are benign from malignant renal cell carcinomas (RCCs), leading to unnecessary surgical resection and resulting morbidity associated with surgery. Here, we investigated hyperpolarized

Indexed as

aerobic glycolysisdynamic nuclear polarization (DNP)Hyperpolarized 13C magnetic resonance (HP 13C MR)lactate effluxpatient-derived tissue slice culturesrenal cell carcinoma (RCC)

Identifiers

PMID27227168
PMCPMC4876723
OpenAlexW2471552358

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.